From Synthesis to Biological Impact of Ru (II) Complexes: Preparation, Characterization, Antimicrobial, Antioxidant scavenging and Enzymatic inhibitory activities

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dc.authoridGurbuz, Nevin/0000-0003-3201-3597;
dc.authorwosidGurbuz, Nevin/A-3069-2016
dc.authorwosidOZDEMIR, ISMAIL/KVY-3420-2024
dc.contributor.authorAmri, Nasser
dc.contributor.authorMukhrish, Yousef E.
dc.contributor.authorGatri, Rafik
dc.contributor.authorGurbuz, Nevin
dc.contributor.authorOzdemir, Ismail
dc.contributor.authorDridi, Khaireddine
dc.contributor.authorHamdi, Naceur
dc.date.accessioned2024-08-04T20:54:27Z
dc.date.available2024-08-04T20:54:27Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe reaction of [RuCl2(p-cymene)]2 with in situ prepared Ag-N-heterocyclic carbene (NHC) complexes yields a series of [RuCl2(p-cymene) (NHC)] complexes 3. The structures of complexes were established by appropriate spectroscopic methods and elemental analyses. The biological activities of the synthesized ligands and their Ru (II) complexes as acetylcholinesterase, antimicrobial, and antioxidant agents were evaluated. The lowest MICs values were obtained with the two complexes 3b and 3d. The enzymatic inhibitory investigation against acetylcholinesterase (AChE) and tyrosinase (TyrE), showed that the two complexes 3b and 3d are the most potent inhibitors against (AchE) with an IC50 of 2.52 and 5.06 & mu;g mL-1 respectively, and against (TyrE) with an IC50 of 19.88 and 24.95 & mu;g mL-1 respectively. Additionally, DPPH (2,2-diphenyl-1-picrylhydrazyl) has been tested for its ability to scavenge hydrogen peroxide and free radicals. According to our results, these compounds exhibiten_US
dc.identifier.doi10.21608/EJCHEM.2023.122780.5495
dc.identifier.endpage214en_US
dc.identifier.issn0449-2285
dc.identifier.issn2357-0245
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-85162860547en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage203en_US
dc.identifier.urihttps://doi.org/10.21608/EJCHEM.2023.122780.5495
dc.identifier.urihttps://hdl.handle.net/11616/101423
dc.identifier.volume66en_US
dc.identifier.wosWOS:001015023000021en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherNatl Inform & Document Centreen_US
dc.relation.ispartofEgyptian Journal of Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectStrucutre analysisen_US
dc.subjectCatalystsen_US
dc.subjectCatalysisen_US
dc.subjectBiological activityen_US
dc.subjectN-Heterocyclic carbeneen_US
dc.subjectbenzimidazolium saltsen_US
dc.subjectruthenium complexesen_US
dc.subjectsilver complexesen_US
dc.titleFrom Synthesis to Biological Impact of Ru (II) Complexes: Preparation, Characterization, Antimicrobial, Antioxidant scavenging and Enzymatic inhibitory activitiesen_US
dc.typeArticleen_US

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