Protective role of ?-tocopherol and caffeic acid phenethyl ester on ischemia-reperfusion injury via nitric oxide and myeloperoxidase in rat kidneys

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dc.authoridArmutcu, Ferah/0000-0002-3218-9480
dc.authoridKutlu, Nurettin Onur/0000-0002-3306-6570
dc.authoridOZYURT, Huseyin/0000-0003-2327-4082
dc.authorwosidArmutcu, Ferah/A-1364-2019
dc.authorwosidKutlu, Nurettin Onur/AAW-6196-2021
dc.authorwosidOZYURT, Huseyin/N-4351-2015
dc.contributor.authorGurel, A
dc.contributor.authorArmutcu, F
dc.contributor.authorSahin, S
dc.contributor.authorSogut, S
dc.contributor.authorOzyurt, H
dc.contributor.authorGulec, M
dc.contributor.authorKutlu, NO
dc.date.accessioned2024-08-04T20:13:36Z
dc.date.available2024-08-04T20:13:36Z
dc.date.issued2004
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: The aim of this study was to determine the acute effects of antioxidant caffeic acid phenethyl ester (CAPE) and alpha-tocopherol (vitamin E) on nitric oxide (NO) production, neutrophil infiltration, and antioxidant enzyme activities on an in vivo model of renal ischemia-reperfusion injury. Methods: Rats were divided into five equal groups each consisting six rats: sham operation, ischemia, ischemia-reperfusion (I/R), I/R plus CAPE, and I/R plus vitamin E groups. CAPE or vitamin E was administered intraperitoneally before reperfusion. After experimental procedure, rats were sacrificed and both ipsilateral and contralateral kidneys were removed and prepared for NO concentrations, myeloperoxidase (MPO), catalase (CAT) and superoxide dismutase (SOD) activities. Results: Acute administration of vitamin E decreased NO concentrations in both ipsilateral and contralateral renal tissues compared to I/R group. SOD activity was increased in I/R and I/R + CAPE groups compared to sham operation group. The most prominent results were encountered in MPO activities, which did not change in contralateral kidneys in both ischemia and I/R groups. There was a significant decrease in ipsilateral MPO activity in ischemia group and a significant increase in I/R group compared to sham operation group. Pretreatment with intraperitoneal CAPE significantly diminished the tissue MPO activity indicating the prevention of the neutrophil sequestration into the kidney. Conclusion: There is a role for CAPE in attenuation in renal damage after I/R injury of the kidney, in part at least by inhibition of neutrophil sequestration. (C) 2003 Elsevier B.V. All rights reserved.en_US
dc.identifier.doi10.1016/j.cccn.2003.09.013
dc.identifier.endpage41en_US
dc.identifier.issn0009-8981
dc.identifier.issn1873-3492
dc.identifier.issue1-2en_US
dc.identifier.pmid14687891en_US
dc.identifier.scopus2-s2.0-0346996438en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage33en_US
dc.identifier.urihttps://doi.org/10.1016/j.cccn.2003.09.013
dc.identifier.urihttps://hdl.handle.net/11616/93710
dc.identifier.volume339en_US
dc.identifier.wosWOS:000188214900004en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofClinica Chimica Actaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectreperfusion injuryen_US
dc.subjectkidneyen_US
dc.subjectcaffeic acid phenethyl esteren_US
dc.subjectalpha-tocopherolen_US
dc.subjectnitric oxideen_US
dc.subjectantioxidant enzymesen_US
dc.titleProtective role of ?-tocopherol and caffeic acid phenethyl ester on ischemia-reperfusion injury via nitric oxide and myeloperoxidase in rat kidneysen_US
dc.typeArticleen_US

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