Synthesis, structural characterizations and in vitro cytotoxic activities of new sulfonamide-based Schiff base derivatives

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dc.authorwosidŞAHAL, HAKAN/JDN-1557-2023
dc.authorwosidöz, samet/HKO-7583-2023
dc.contributor.authorSahal, Hakan
dc.contributor.authorOz, Samet
dc.contributor.authorTekin, Suat
dc.contributor.authorCanpolat, Erdal
dc.date.accessioned2024-08-04T20:52:05Z
dc.date.available2024-08-04T20:52:05Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractSynthesis of five different new compounds (1-5) were carried out. Their structures were characterized by spectroscopic methods such as Fourier transform infrared, Proton nuclear magnetic resonance, Carbon-13 nuclear magnetic resonance and Elemental analysis. Cytotoxic activities of five new sulfonamide based-Schiff base compounds were determined by MTT assay using A-2780 (human ovarian cancer) and MCF-7 (breast cancer) cell lines. LogIC(50) values of the sulfonamide derivates compounds were calculated by Graphpad Prism 12 programme after a 24-hour treatment for A2780 and MCF-7 cells. Comet assay experiments were performed to determine DNA damage using LogIC(50) concentrations of all compounds in A2780 and MCF-7 cells. All compounds significantly reduced A2780 and MCF-7 cell viability compared to control groups (p < 0.05). In addition, all compounds caused DNA damage in A2780 and MCF-7 cells (p < 0.05). These results show that the synthesized compounds exhibit cytotoxic effects against cancer cells and that the cause of cell death is due to DNA damage. Communicated by Ramaswamy H. Sarmaen_US
dc.identifier.doi10.1080/07391102.2022.2067237
dc.identifier.endpage4367en_US
dc.identifier.issn0739-1102
dc.identifier.issn1538-0254
dc.identifier.issue10en_US
dc.identifier.pmid35477366en_US
dc.identifier.scopus2-s2.0-85132650225en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage4361en_US
dc.identifier.urihttps://doi.org/10.1080/07391102.2022.2067237
dc.identifier.urihttps://hdl.handle.net/11616/100737
dc.identifier.volume41en_US
dc.identifier.wosWOS:000788531000001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofJournal of Biomolecular Structure & Dynamicsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSulfonamide derivativeen_US
dc.subjectSchiff baseen_US
dc.subjectspectroscopicen_US
dc.subjectcytotoxic activityen_US
dc.subjectcancer cell linesen_US
dc.subjectDNA damageen_US
dc.titleSynthesis, structural characterizations and in vitro cytotoxic activities of new sulfonamide-based Schiff base derivativesen_US
dc.typeArticleen_US

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