Fatty liver disease in an autopsy series of children and adolescents

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dc.authoridÇelik, Nurullah/0000-0003-1583-6807
dc.authoridYüksel, Fadime/0000-0001-5390-9590
dc.authoridTurkmen, Samdanci, Emine/0000-0002-0034-5186
dc.authoridYuksel, Ilhami/0000-0002-9730-2309
dc.authorwosidÇelik, Nurullah/AAS-4282-2021
dc.authorwosidYüksel, Fadime/ABG-8023-2020
dc.authorwosidTurkmen, Samdanci, Emine/ABH-4716-2020
dc.authorwosidYuksel, Ilhami/O-5346-2017
dc.contributor.authorYuksel, F.
dc.contributor.authorTurkkan, D.
dc.contributor.authorYuksel, I
dc.contributor.authorKara, S.
dc.contributor.authorCelik, N.
dc.contributor.authorSamdanci, E. T.
dc.date.accessioned2024-08-04T20:35:42Z
dc.date.available2024-08-04T20:35:42Z
dc.date.issued2012
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground and Aims: Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in children and adolescents. Obesity is a major risk factor for NAFLD; however, it has been shown that NAFLD is not rare in nonobese adults. The aim of this study was to determine the prevalence of NAFLD in obese and non-obese children and adolescents. Methods: The medical records of 340 subjects (aged 2-20 years) in whom autopsy was performed were retrospectively reviewed. Of those, 10 subjects were excluded due to insufficient data. The remaining 330 subjects were included in the study, of whom 264 were normal weight and 66 were obese. All liver biopsy sections were evaluated by two pathologists in a blinded fashion. Results: The prevalence of fatty liver was 6% among all the subjects and was higher in the overweight group than in the normal-weight group (10.6% vs 4.9%; p<0.001). The prevalence of NAFLD increased concomitant with age. There was no significant difference between sexes in cases with NAFLD. Simple steatosis was detected in 7 subjects. Steatohepatitis was determined as type 1 in 5 subjects, type 2 in 7 subjects, and as overlap in 1 subject. Conclusions: This study demonstrated that NAFLD is an important public health problem not only in obese but also in non-obese children and adolescents. This suggests that whereas obesity may be a risk factor, other pathogenic factors may exist that could contribute to the NAFLD. Hippokratia. 2012; 16(1): 61-65en_US
dc.identifier.endpage65en_US
dc.identifier.issn1108-4189
dc.identifier.issue1en_US
dc.identifier.pmid23930060en_US
dc.identifier.scopus2-s2.0-84855425456en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage61en_US
dc.identifier.urihttps://hdl.handle.net/11616/95529
dc.identifier.volume16en_US
dc.identifier.wosWOS:000299757900011en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLithographiaen_US
dc.relation.ispartofHippokratiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectfatty liver diseaseen_US
dc.subjectobesityen_US
dc.subjectchildrenen_US
dc.subjectadolescentsen_US
dc.subjectautopsyen_US
dc.titleFatty liver disease in an autopsy series of children and adolescentsen_US
dc.typeArticleen_US

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