Determination of in vitro dissolution profiles of amlodipine besylate and olmesartan medoxomil using a new "HPLC method"

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dc.authorscopusid14032701900
dc.authorscopusid16641914100
dc.authorscopusid56666885900
dc.authorscopusid55904870700
dc.contributor.authorKaynak M.S.
dc.contributor.authorÇelebier M.
dc.contributor.authorSahin S.
dc.contributor.authorAltinöz S.
dc.date.accessioned2024-08-04T19:59:13Z
dc.date.available2024-08-04T19:59:13Z
dc.date.issued2013
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe aim of this study was to develop an HPLC method for simultaneous determination of these active compounds and to apply this method to determine the dissolution of AML and OLM from a commercially available tablet. Valsartan (VAL) was used as an internal standard (IS). Separation of AML, OLM and VAL was performed using Phenomenex C18 column (Luna 5 ?, 100A, 250x4.6 mm; California, USA) protected with a Phenomenex C18 guard column (4.0x3.0 mm; California, USA). The chromatographic separation operated isocratically at room temperature using a mobile phase consisted of phosphate buffer (pH 4.0,0.04 mol/L):methanol: acetonitrile (40:45:15, v/v/v) delivered at a flow rate of 0.8 mL/min and injection volume was 10 ?L. The diode array detector was set at 234 nm and 205 nm wavelengths for the quantirication of AML and OLM respectively. In vitro dissolution studies revealed that 85% of the labeled amounts of AML and OLM were released within 25 min from their fixed combination tablet dosage form. The developed HPLC method was validated according to the ICH guidelines and it is proposed for dissolution studies of the combination dosage forms of these compounds.en_US
dc.identifier.endpage30en_US
dc.identifier.issn0034-7752
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-84874897483en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage27en_US
dc.identifier.urihttps://hdl.handle.net/11616/90465
dc.identifier.volume64en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSyscom 18 SRLen_US
dc.relation.ispartofRevista de Chimieen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAmlodipine besylateen_US
dc.subjectDissolutionen_US
dc.subjectHPLC methoden_US
dc.subjectOlmesartan medoxomilen_US
dc.titleDetermination of in vitro dissolution profiles of amlodipine besylate and olmesartan medoxomil using a new "HPLC method"en_US
dc.typeArticleen_US

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