Role of Adenosine Deaminase in Patients with Erythematotelan-giectatic Rosacea and Demodex folliculorum Positivity

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dc.authoridKIRAN, TUGBA RAIKA/0000-0002-3724-0249
dc.authoridKıran, Tugba Raika/0000-0002-3724-0249
dc.authoridÇOLAK, CEMİL/0000-0001-5406-098X
dc.authorwosidKIRAN, TUGBA RAIKA/AAA-8224-2021
dc.authorwosidKıran, Tugba Raika/HFZ-9643-2022
dc.authorwosidDirekel, Sahin/ABG-1575-2020
dc.authorwosidÇOLAK, CEMİL/ABI-3261-2020
dc.contributor.authorSener, Serpil
dc.contributor.authorKaraman, Ulku
dc.contributor.authorKiran, Tugba Raika
dc.contributor.authorColak, Cemil
dc.contributor.authorAslan, Ali
dc.contributor.authorDirekel, Sahin
dc.date.accessioned2024-08-04T20:49:07Z
dc.date.available2024-08-04T20:49:07Z
dc.date.issued2020
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: Adenosine deaminase (ADA) is an aminohydrolase involved in the catabolism of purine nucleotides and irreversibly deaminizes adenosine and deoxyadenosine to inosine and deoxyinosine. ADA enzyme deficiency results in the loss of functional properties of B and T lymphocytes. Demodex species have been reported to be transmitted between humans through close contact and to play a role in the pathogenesis of rosacea, acne vulgaris, perioral dermatitis, seborrhoeic dermatitis, micropapillary-pruritic dermatitis and blepharitis. The present study aimed to compare serum ADA levels in D. foaculorum positive patients with the healthy control individuals. Methods: Serum ADA levels were examined for 30 patients diagnosed with erythematotelangiectatic rosacea and 40 healthy individuals in Malatya Inonu University in 2017. Standardized skin surface biopsy (SSSB) method was used to diagnose D. foliculorum. A significant decrease was found in the ADA levels of Demodex-positive rosacea patients when compared to the control group. Results: ADA levels were decreased in the Demodex-positive group. The mean ADA level in patient group was significantly lower than the mean in the control group (P<0.001). There was no significant difference between the patient and control groups in terms of age and gender. Conclusion: During and after treatment of Demodex-positive rosacea patients, determination of ADA levels may give more detailed information on the immune mechanisms.en_US
dc.identifier.endpage601en_US
dc.identifier.issn1735-7020
dc.identifier.issn2008-238X
dc.identifier.issue4en_US
dc.identifier.pmid33884017en_US
dc.identifier.scopus2-s2.0-85097443226en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage596en_US
dc.identifier.urihttps://hdl.handle.net/11616/99666
dc.identifier.volume15en_US
dc.identifier.wosWOS:000599592000015en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherIranian Scientific Society Medical Entomologyen_US
dc.relation.ispartofIranian Journal of Parasitologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAdenosine deaminase levelen_US
dc.subjectDemodex folliculorumen_US
dc.subjectErvthematotelangiectatic rosaceaen_US
dc.titleRole of Adenosine Deaminase in Patients with Erythematotelan-giectatic Rosacea and Demodex folliculorum Positivityen_US
dc.typeArticleen_US

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