Effects of melatonin and acetylsalicylic acid against hepatic oxidative stress after bile duct ligation in rat

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dc.authoridEşrefoğlu, Mukaddes/0000-0003-3380-1480
dc.authoridGül, Mehmet/0000-0002-1374-0783
dc.authoridPolat, Alaadin/0000-0002-6920-3856
dc.authoridbay karabulut, aysun/0000-0002-7873-2805
dc.authorwosidEşrefoğlu, Mukaddes/JWA-4590-2024
dc.authorwosidGül, Mehmet/ABI-6336-2020
dc.authorwosidPolat, Alaadin/AAA-7171-2021
dc.authorwosidbay karabulut, aysun/HJP-0995-2023
dc.contributor.authorEmre, M. H.
dc.contributor.authorPolat, A.
dc.contributor.authorEsrefoglu, M.
dc.contributor.authorKarabulut, A. B.
dc.contributor.authorGul, M.
dc.date.accessioned2024-08-04T20:31:01Z
dc.date.available2024-08-04T20:31:01Z
dc.date.issued2008
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe aim of this study was to assess the effect of melatonin and acetylsalicylic acid (ASA) on hepatic damage induced by bile duct ligation (BDL) Material and methods: Male Sprague-Dawley rats were subjected to either sham operation or common BDL before treatment with ASA, melatonin or vehicle. Hepatic superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px) enzyme activities and reduced glutathione (GSH), malondialdehyde (MDA) and nitric oxide (NO) levels were evaluated. Results: Our results have indicated that BDL caused a significant increase in lipid peroxidation whereas a statistically insignificant decrease in GSH level and some of the antioxidant enzyme activities. Both MEL and ASA administrations, either separately or together, decreased MDA whereas co-administration of MEL with ASA increased GSH levels in BDL rats. Conclusions: CAT activity and MEL level decreased in the liver tissues of rats with BDL after administration of either melatonin alone or with ASA. However, melatonin and ASA administration increases liver tissue GSH levels in BDL ligated ratsen_US
dc.identifier.doi10.1556/APhysiol.2008.0001
dc.identifier.endpage363en_US
dc.identifier.issn0231-424X
dc.identifier.issn1588-2683
dc.identifier.issue4en_US
dc.identifier.pmid19009911en_US
dc.identifier.scopus2-s2.0-54949101112en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage349en_US
dc.identifier.urihttps://doi.org/10.1556/APhysiol.2008.0001
dc.identifier.urihttps://hdl.handle.net/11616/94680
dc.identifier.volume95en_US
dc.identifier.wosWOS:000260825300003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAkademiai Kiado Zrten_US
dc.relation.ispartofActa Physiologica Hungaricaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectmelatoninen_US
dc.subjectacetylsalicylic aciden_US
dc.subjectantioxidant enzymesen_US
dc.subjectMDAen_US
dc.subjectNOen_US
dc.subjectGSHen_US
dc.titleEffects of melatonin and acetylsalicylic acid against hepatic oxidative stress after bile duct ligation in raten_US
dc.typeArticleen_US

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