Hyperbaric bupivacaine affects the doses of midazolam required for sedation after spinal anaesthesia

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dc.authoridErsoy, Mehmet/0000-0002-0724-2825
dc.authoridbegeç, zekine/0000-0002-9506-1871
dc.authoridToprak, Hüseyin İlksen/0000-0001-9293-8116
dc.authoridUlger, Hacer/0000-0002-8579-0528
dc.authorwosidErsoy, Mehmet/ACN-2779-2022
dc.authorwosidUlger, Hacer/AAI-8829-2021
dc.authorwosidbegeç, zekine/ABI-5491-2020
dc.authorwosidToprak, Hüseyin İlksen/AAN-4023-2020
dc.authorwosidSağır, Özlem/AAS-5880-2020
dc.contributor.authorToprak, HI
dc.contributor.authorOzpolat, Z
dc.contributor.authorOzturk, E
dc.contributor.authorUlger, MH
dc.contributor.authorSagir, O
dc.contributor.authorErsoy, MO
dc.date.accessioned2024-08-04T20:15:06Z
dc.date.available2024-08-04T20:15:06Z
dc.date.issued2005
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground and objective: Patients having spinal anaesthesia with hyperbaric bupivacaine may become sensitive to sedative drugs but no data exists about any dose-related effect of the local anaesthetic on the sedative requirement. We aimed to investigate whether hyperbaric bupivacaine dose in spinal anaesthesia has any effect on midazolam requirements. Methods: Sixty unpremedicated patients were allocated to three equal groups. Patients in Groups I and II received hyperbaric bupivacaine 0.5% 10 and 17.5 mg respectively for spinal anaesthesia and Group III was a control group without spinal anaesthesia. In Groups I and II, after the evaluation of sensory block, patients received intravenous midazolam I mg per 30 s until the Ramsay sedation score reached 3 (drowsy but responsive to command). In Group III, general anaesthesia was induced after sedation score had reached 3 using midazolam. The total dose of midazolam (mg kg(-1)) given to each patient, the level of sensory block and complications were recorded. Results: The level of sensory block was higher in Group II (T7) than Group I (T9) (P < 0.01). The doses of midazolam were 0.063 mg kg(-1) in Group I, 0.065 mg kg(-1) in Group II and 0.101 mg kg(-1) in Group III (P < 0.001). There was no correlation between level of sensory block and dose of midazolam in Group I (r = -0.293, P = 0.21) and Group II (r = 0.204, P = 0.39). Conclusions: Different doses of hyperbaric bupivacaine for spinal anaesthesia do not affect the midazolam requirements for sedation. However, spinal anaesthesia with hyperbaric bupivacaine with a maximum spread in the middle thoracic dermatomes may be associated with sedative effects and thus a reduced need for further sedation with midazolam.en_US
dc.identifier.doi10.1017/S0265021505001535
dc.identifier.endpage906en_US
dc.identifier.issn0265-0215
dc.identifier.issn1365-2346
dc.identifier.issue12en_US
dc.identifier.pmid16318659en_US
dc.identifier.scopus2-s2.0-28444439586en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage904en_US
dc.identifier.urihttps://doi.org/10.1017/S0265021505001535
dc.identifier.urihttps://hdl.handle.net/11616/94176
dc.identifier.volume22en_US
dc.identifier.wosWOS:000233719400002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofEuropean Journal of Anaesthesiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectanaesthetic techniques, spinalen_US
dc.subjectanaesthetic local, bupivacaineen_US
dc.subjectsedative agents, midazolamen_US
dc.subjectsedationen_US
dc.titleHyperbaric bupivacaine affects the doses of midazolam required for sedation after spinal anaesthesiaen_US
dc.typeArticleen_US

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