Protective effects of hesperidin in experimental testicular ischemia/reperfusion injury in rats

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dc.authoridTurtay, Muhammet Gokhan/0000-0002-1728-8237
dc.authoridOguzturk, Hakan/0000-0002-9800-1428
dc.authoridCiftci, Osman/0000-0001-5755-3560
dc.authorwosidTurtay, Muhammet Gokhan/ABG-7401-2020
dc.authorwosidoguzturk, hakan/Q-6242-2019
dc.authorwosidOguzturk, Hakan/AAC-3915-2021
dc.contributor.authorCelik, Emrah
dc.contributor.authorOguzturk, Hakan
dc.contributor.authorSahin, Nurhan
dc.contributor.authorTurtay, Muhammet Gokhan
dc.contributor.authorOguz, Fatih
dc.contributor.authorCiftci, Osman
dc.date.accessioned2024-08-04T20:42:41Z
dc.date.available2024-08-04T20:42:41Z
dc.date.issued2016
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIntroduction: In this study, we aimed to determine the protective effects of hesperidin, a citrus flavonoid, in a model of testicular ischemia/reperfusion injury in rats. Material and methods: Forty-two pubertal male Wistar-Albino rats were divided into six groups: group 1 - control; group 2 - 50 mg/kg hesperidin (low dose hesperidin) used without torsion (LH group); group 3 - 100 mg/kg hesperidin without torsion (HH group); group 4 - torsion/detorsion group (T/D); group 5 - T/D + 50 mg/kg hesperidin treatment group (T/D + LH); and group 6 - T/D + 100 mg/kg hesperidin treatment group (T/D + HH). Hesperidin was given to the treatment groups 30 min before detorsion. After the fourth hour of reperfusion, orchiectomy was performed on the rats under anesthesia. The tissue samples were examined histologically and biochemically. Results: In the T/D group testicular malondialdehyde (MDA) levels were increased significantly (p < 0.001) whereas superoxide dismutase (SOD), catalase (CAT) and glutathione (GSH) levels were decreased compared to the control and other groups. However, hesperidin caused the effect of T/D to become closer to normal biochemical values. In addition, the histological examinations showed that T/D caused damage in the testis but hesperidin reduced this effect. The effects of hesperidin were found to be dose dependent. Thus, applying high doses would generate greater therapeutic effects. Conclusions: In a rat testicular T/D model we observed biochemical and histological damage due to ischemia. However, high and low dose applications of hesperidin were shown to have protective effects against this damage. Therefore, the aforementioned citrus flavonoid may provide positive results in cases of testicular torsion.en_US
dc.description.sponsorshipInonu Universityen_US
dc.description.sponsorshipThis research was supported by the Inonu University Scientific Research Project.en_US
dc.identifier.doi10.5114/aoms.2015.47697
dc.identifier.endpage934en_US
dc.identifier.issn1734-1922
dc.identifier.issn1896-9151
dc.identifier.issue5en_US
dc.identifier.pmid27695481en_US
dc.identifier.scopus2-s2.0-84989968040en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage928en_US
dc.identifier.urihttps://doi.org/10.5114/aoms.2015.47697
dc.identifier.urihttps://hdl.handle.net/11616/97521
dc.identifier.volume12en_US
dc.identifier.wosWOS:000382410700002en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTermedia Publishing House Ltden_US
dc.relation.ispartofArchives of Medical Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjecthesperidinen_US
dc.subjecttesticular torsion-detorsionen_US
dc.subjectischemia-reperfusion injury in the raten_US
dc.titleProtective effects of hesperidin in experimental testicular ischemia/reperfusion injury in ratsen_US
dc.typeArticleen_US

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