Analysis of vitamin d receptor polymorphisms in patients with familial multiple sclerosis
| dc.contributor.author | Yucel, F.E. | |
| dc.contributor.author | Kamıslı, O. | |
| dc.contributor.author | Acar, C. | |
| dc.contributor.author | Sozen, M. | |
| dc.contributor.author | Tecellioğlu, M. | |
| dc.contributor.author | Ozcan, C. | |
| dc.date.accessioned | 2019-07-04T10:54:15Z | |
| dc.date.available | 2019-07-04T10:54:15Z | |
| dc.date.issued | 2018 | |
| dc.department | İnönü Üniversitesi | en_US |
| dc.description.abstract | Objective: Genetic and environmental factors are important in the development of the multiple sclerosis (MS). Vitamin D shows its effects on the immune system with the vitamin D receptor (VDR) in the nucleus. Single nucleotide polymorphisms (SNPs) in the VDR gene can lead to alterations in vitamin D functions and metabolism.Taq I, Apa I, Fok I and Bsm I polymorphisms and MS associations have been investigated in many studies. VDR gene polymorphism has not been previously studied in patients with familial MS. Aim: We aimed to investigate the relationship between familial MS patients present in Turkish population and VDR genotypes Taq I, Apa I and Fok I polymorphisms. Methods: 29 patients with a family history of MS and 120 healthy control subjects were included in the present study. We studied present VDR genotypes Taq I, Apa I and Fok I polymorphisms. Results: We observed a significant difference between controls and patient group only in Taq I polymorphism (p: 0.025). Homozygousity of G allele was not seen in the patients whereas in controls frequency of that genotype was p:0.208. When gender was considered males show significant difference for GG genotype. There were no significant association for the Apa I and Fok I polymorphisms. Conclusion: Although our findings suggest association between VDR Taq I polymorphism and the familial MS, additional studies are needed to establish detailed relationships. | en_US |
| dc.identifier.citation | Yucel, F.E. Kamıslı, O. Acar, C. Sozen, M. Tecellioğlu, M. Ozcan, C. (2018). Analysis of vitamin d receptor polymorphisms in patients with familial multiple sclerosis. Cilt:72 Sayı:1, 28-61 ss. | en_US |
| dc.identifier.doi | 10.5455/medarh.2017.72.58-61 | en_US |
| dc.identifier.endpage | 61 | en_US |
| dc.identifier.issue | 1 | en_US |
| dc.identifier.startpage | 28 | en_US |
| dc.identifier.uri | https://hdl.handle.net/11616/12326 | |
| dc.identifier.volume | 72 | en_US |
| dc.language.iso | en | en_US |
| dc.rights | info:eu-repo/semantics/openAccess | en_US |
| dc.subject | Familial Multiple Sclerosis | en_US |
| dc.subject | Multiple Sclerosis | en_US |
| dc.subject | Vitamin DVitamin | en_US |
| dc.subject | D receptor polymorphisms | en_US |
| dc.title | Analysis of vitamin d receptor polymorphisms in patients with familial multiple sclerosis | en_US |
| dc.type | Article | en_US |
