Ephedra alata Growing Wild in Southern Tunisia: Phytochemical Profiling and Anti-Inflammatory, Antibacterial, Anti-xanthine Oxidase and Cytotoxic Potentials

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dc.contributor.authorBennour, Naima
dc.contributor.authorMighri, Hedi
dc.contributor.authorHarboub, Nesrine
dc.contributor.authorEljani, Hajer
dc.contributor.authorChouikhi, Naima
dc.contributor.authorYesilada, Ozfer
dc.contributor.authorCampra, Pablo
dc.date.accessioned2026-04-04T13:32:56Z
dc.date.available2026-04-04T13:32:56Z
dc.date.issued2026
dc.departmentİnönü Üniversitesi
dc.description.abstractThis study investigated the ethnobotanical use, phytochemical composition, and biological activities of Ephedra alata from southern Tunisia. Ethnobotanical data were collected via an online questionnaire, and proximate, phytochemical, and mineral analyses were performed using standard methods. Extracts obtained with dichloromethane, ethyl acetate, butanol, ethanol, and water were assessed for total phenolic content (TPC) and total flavonoid content (TFC), as well as for anti-inflammatory (5-lipoxygenase inhibition), anti-xanthine oxidase, cytotoxic (HT-29 cell line), and antibacterial (MIC against Staphylococcus aureus and Escherichia coli) activities. Among 450 respondents, 64% were familiar with Ephedra and 27% reported its use mainly aerial parts via infusion for cancer, digestive issues, and hypertension. Nutritional analysis revealed high fiber (41.6%), protein (9.45%), and mineral content. Phytochemical screening identified 9 of 17 targeted compounds. Mineral analysis confirmed the presence of Na, K, Ca, Mg, Zn, and Fe. Ethanol extracts showed the highest anti-xanthine oxidase (IC50 = 143mg/L) and cytotoxic activity (GI50= 780mg/L), while overall anti-inflammatory and antibacterial effects were weak. These findings support the traditional use of E. alata and highlight its potential in health and nutrition applications.
dc.identifier.doi10.21608/ejbo.2025.358314.3178
dc.identifier.endpage54
dc.identifier.issn0375-9237
dc.identifier.issn2357-0350
dc.identifier.issue1
dc.identifier.scopus2-s2.0-105026172897
dc.identifier.scopusqualityQ3
dc.identifier.startpage43
dc.identifier.urihttps://doi.org/10.21608/ejbo.2025.358314.3178
dc.identifier.urihttps://hdl.handle.net/11616/108809
dc.identifier.volume66
dc.identifier.wosWOS:001694808500004
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherNatl Information Documentation Cent, Acad Scientific Research & Technology
dc.relation.ispartofEgyptian Journal of Botany
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250329
dc.subjectBiological activities
dc.subjectEphedra alata
dc.subjectEthnobotanical survey
dc.subjectMineral composition
dc.subjectPhytochemical screening
dc.subjectProximate analysis
dc.titleEphedra alata Growing Wild in Southern Tunisia: Phytochemical Profiling and Anti-Inflammatory, Antibacterial, Anti-xanthine Oxidase and Cytotoxic Potentials
dc.typeArticle

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