Effects of intrathecal fentanyl or meperidine addition to bupivacaine on hemodynamic variables, postoperative analgesic requirements, levels of histamine, IgE, basophiles and eosinophiles

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dc.authorscopusid6603851680
dc.authorscopusid57196857711
dc.authorscopusid7004621949
dc.authorscopusid6603402358
dc.authorscopusid6603951627
dc.authorscopusid7004486274
dc.contributor.authorKöro?lu A.
dc.contributor.authorErdem S.
dc.contributor.authorÇiçek M.
dc.contributor.authorDo?an Z.
dc.contributor.authorSezgin N.
dc.contributor.authorErsoy M.O.
dc.date.accessioned2024-08-04T20:00:59Z
dc.date.available2024-08-04T20:00:59Z
dc.date.issued2003
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe aim of our study is to compare the effects of intrathecal fentanyl and meperidine with bupivacaine on hemodynamics, postoperative analgesic requirement, side effects and levels of histamine, IgE, basophiles, eosinophiles and to investigate a possible relationship between itching and levels of basophiles and eosinophiles. Heart rate, mean arterial pressure, SpO2 values, respiration rates of 45 cases were recorded before and after spinal anesthesia. Intrathecal 10mg bupivacaine heavy was used in combination with 0.5 mL 0.9% NaCl in group B, 25 ?g fentanyl in group F, 25 mg meperidine in group M were given. Blood samples were collected to determine the plasma levels of histamine, IgE, basophiles and eosinophiles 30 min before spinal anaesthesia, and at the 8th, 60th minutes of spinal anaesthesia. Analgesic requirement was evaluated for postoperative 24 hours by using VAS. Although plasma levels of histamine and basophiles were significantly higher in group M and F at the 8th, 60th min of spinal anaesthesia, levels of histamine were significantly higher in group M than other two groups at the 8th min of spinal anaesthesia. VAS scores and analgesic requirements were significantly lower in group M than the other two groups at late postoperative period. Itching and vomiting incidences were higher in group F and there was no relationship between itching and levels of eosinophiles and basophiles. In conclusion, we determined that intrathecal fentanyl and meperidine did not effect hemodynamics, and meperidine provided better analgesia in the postoperative period. Although, histamine release increased with both opioids, it was more in meperidine than fentanyl, however fentanyl caused more vomiting and itching. There was no relationship between levels of eosinophiles, basophiles and itching.en_US
dc.identifier.endpage183en_US
dc.identifier.issn1300-0578
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-0141988532en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage177en_US
dc.identifier.urihttps://hdl.handle.net/11616/91143
dc.identifier.volume11en_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.relation.ispartofAnestezi Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFentanylen_US
dc.subjectItchingen_US
dc.subjectMeperidineen_US
dc.subjectPostoperative analgesiaen_US
dc.subjectSpinal anesthesiaen_US
dc.titleEffects of intrathecal fentanyl or meperidine addition to bupivacaine on hemodynamic variables, postoperative analgesic requirements, levels of histamine, IgE, basophiles and eosinophilesen_US
dc.title.alternative?Intratekal bupivakaine fentanil veya meperidin eklenmesinin hemodinami, postoperatif analjezik gereksinimi, histamin, IgE, bazofil ve eozinofil seviyelerine etkisien_US
dc.typeArticleen_US

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