Calculation of melatonin and resveratrol effects on steatosis hepatis using soft computing methods

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dc.authoridGül, Mehmet/0000-0002-1374-0783
dc.authoridTalu, Muhammed Fatih/0000-0003-1166-8404
dc.authoridALPASLAN, Nuh/0000-0002-6828-755X
dc.authorwosidGül, Mehmet/ABI-6336-2020
dc.authorwosidTalu, Muhammed Fatih/W-2834-2017
dc.authorwosidALPASLAN, Nuh/B-2199-2018
dc.contributor.authorTalu, M. Fatih
dc.contributor.authorGul, Mehmet
dc.contributor.authorAlpaslan, Nuh
dc.contributor.authorYigitcan, Birgul
dc.date.accessioned2024-08-04T20:37:42Z
dc.date.available2024-08-04T20:37:42Z
dc.date.issued2013
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIn this work, beneficial effects of melatonin and resveratrol drugs on liver damage in rats, induced by application of acute and chronic carbon tetrachloride (CCl4) have been examined. The study consists of three main stages: (1) Data acquisition: light microscopic images were obtained from 60 rats separated into 10 groups after the preparation of liver tissue samples for histological examination. Rats in first five experimental groups for the four-day and the other five groups for twenty-day were examined. (2) Data processing: by the help of histograms of oriented gradient (HOG) method, obtaining low-dimensional image features (color, shape and texture) and classifying five different group characteristics by using these features with artificial neural networks (ANNs), and support vector machines (SVMs) have been provided. (3) Calculation of drug effectiveness: firstly to determine the differences between group characteristics of rats, a pilot group has been selected (diseased group-CCl4), and the responses of ANN and SVM trained by HOG features have been calculated. As a result of ANN, it has been seen that melatonin and resveratrol drugs have %65.62-% 75.12 positive effects at the end of the fourth day, %84.12-%98.89 positive effects on healing steatosis hepatis at the end of the twentieth day respectively and as a result of SVM, it has been seen that melatonin and resveratrol drugs have %62.5-%68.75 positive effects at the end of the fourth day, %45.12-%60.89 positive effects on healing steatosis hepatis at the end of the twentieth day respectively. (C) 2013 Elsevier Ireland Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.cmpb.2013.04.020
dc.identifier.endpage506en_US
dc.identifier.issn0169-2607
dc.identifier.issn1872-7565
dc.identifier.issue2en_US
dc.identifier.pmid23746907en_US
dc.identifier.scopus2-s2.0-84880038282en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage498en_US
dc.identifier.urihttps://doi.org/10.1016/j.cmpb.2013.04.020
dc.identifier.urihttps://hdl.handle.net/11616/96129
dc.identifier.volume111en_US
dc.identifier.wosWOS:000321345400023en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Ireland Ltden_US
dc.relation.ispartofComputer Methods and Programs in Biomedicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectANNen_US
dc.subjectSVMen_US
dc.subjectHOGen_US
dc.subjectMelatoninen_US
dc.subjectResveratrolen_US
dc.titleCalculation of melatonin and resveratrol effects on steatosis hepatis using soft computing methodsen_US
dc.typeArticleen_US

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