A Schiff base derivative for effective treatment of diethylnitrosamine-induced liver cancer in vivo

Basit Öğe Kaydı
dc.authoridsahin, nurhan/0000-0001-9487-1154
dc.authoridTelci, Dilek/0000-0002-2793-6533
dc.authoridDoğan, Ayşegül/0000-0003-4160-2270
dc.authoridSahin, Kazim/0000-0001-9542-5244
dc.authoridDede, Bülent/0000-0003-1416-7373
dc.authoridbasak, nese/0000-0001-5566-8321
dc.authoridOrhan, Cemal/0000-0003-4138-7689
dc.authorwosidsahin, nurhan/ABF-8007-2020
dc.authorwosidDemirci, Selami/AAC-9963-2020
dc.authorwosidTelci, Dilek/N-5053-2019
dc.authorwosidDoğan, Ayşegül/AAD-3223-2019
dc.authorwosidSahin, Kazim/D-5625-2009
dc.authorwosidDede, Bülent/HIZ-5767-2022
dc.authorwosidbasak, nese/ABH-5495-2020
dc.contributor.authorDemirci, Selami
dc.contributor.authorDogan, Aysegul
dc.contributor.authorBasak, Nese
dc.contributor.authorTelci, Dilek
dc.contributor.authorDede, Bulent
dc.contributor.authorOrhan, Cemal
dc.contributor.authorTuzcu, Mehmet
dc.date.accessioned2024-08-04T20:40:10Z
dc.date.available2024-08-04T20:40:10Z
dc.date.issued2015
dc.departmentİnönü Üniversitesien_US
dc.description.abstractHepatocellular carcinoma is one of the most prevalent cancers, with a high morbidity rate, even in developed countries. In the present study, the curative effect of the Schiff base (SB) heterodinuclear copper(II) Mn(II) complex on diethylnitrosamine (DEN)-induced liver carcinoma was investigated. Hepatocarcinoma was initiated by an injection of DEN and promoted by phenobarbital (0.05%) in the diet. In addition, the potential nephrotoxicity of SB was evaluated in a cisplatin-induced nephrotoxicity model. Rats were administered the SB complex (1 and 2 mg/kg body weight/day) for 24 weeks, and cancer progression was investigated by macroscopic, histopathological, and western blot examinations. The administration of SB decreased the incidence and the number of hepatic nodules in a dose-dependent manner by regulating inflammation response and the apoptotic pathway. Western blot analyses from the livers of rats treated with SB after DEN induction showed significantly enhanced Bax and caspase-3 levels, with a marked decrease in the levels of Bcl-2, NF-kappa B p65 and cyclooxygenase (COX)-2. Results from the nephrotoxicity study showed that, whereas cisplatin increased serum urea nitrogen and creatinine levels, no increase in serum biochemical parameters was detected in SB-treated animals. Moreover, protein levels of NF-E2-related factor-2 (Nrf2) and heme oxygenase-1 were lower, whereas nuclear factor-kappa B (NF-kappa B p65) and activator protein-1 levels were higher in the kidneys of cisplatin-treated animals compared with that of the SB groups. Therefore, the SB complex could be an alternative chemotherapeutic option for liver cancer treatment once its safety in clinical applications has been examined. Copyright (C) 2015 Wolters Kluwer Health, Inc. All rights reserved.en_US
dc.description.sponsorshipYeditepe University; Firat University; Turkish Academy of Sciencesen_US
dc.description.sponsorshipThis work received grants from Yeditepe and Firat Universities. It was also supported in part by the Turkish Academy of Sciences (K.S. and F.S.).en_US
dc.identifier.doi10.1097/CAD.0000000000000221
dc.identifier.endpage564en_US
dc.identifier.issn0959-4973
dc.identifier.issn1473-5741
dc.identifier.issue5en_US
dc.identifier.pmid25714251en_US
dc.identifier.scopus2-s2.0-84928398162en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage555en_US
dc.identifier.urihttps://doi.org/10.1097/CAD.0000000000000221
dc.identifier.urihttps://hdl.handle.net/11616/96761
dc.identifier.volume26en_US
dc.identifier.wosWOS:000352203800009en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofAnti-Cancer Drugsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectdiethylnitrosamineen_US
dc.subjecthepatocarcinogenesisen_US
dc.subjectliver canceren_US
dc.subjectnephrotoxicityen_US
dc.subjectSchiff baseen_US
dc.titleA Schiff base derivative for effective treatment of diethylnitrosamine-induced liver cancer in vivoen_US
dc.typeArticleen_US

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