Non-Infectious Complications in Patients with Allogeneic Hematopoietic Stem Cell Transplantation- Single Center Experience from Eastern Anatolia

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dc.contributor.authorKaraman, Sevtap
dc.contributor.authorSarıcı, Ahmet
dc.contributor.authorErkurt, Mehmet Ali
dc.contributor.authorBiçim, Soykan
dc.contributor.authorHidayet, Emine
dc.contributor.authorKaya, Ahmet
dc.contributor.authorKuku, İrfan
dc.date.accessioned2024-08-04T19:42:31Z
dc.date.available2024-08-04T19:42:31Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIntroduction: The aim of this study was to investigate late non-infectious complications in patients with allogeneic hematopoietic stem cell transplantation (HSCT). Materials and Methods: The records of 143 patients who underwent allogeneic HSCT between 01.02.2011 and 31.12.2018 in Inonu University Turgut Özal Medical Center Department of Hematology were retrospectively reviewed. Results: In our study, late non-infectious complications were seen in 68 % of the patients. Graft Versus Host Disease (GVHD) was observed in 43 patients (33%) %. The most common GVHD involvement sites were skin and liver. It was determined that the number of CD 34 (+) cells had a significant effect on the development of chronic GVHD (p=0,01) and late stage complications (p=0,016). Chronic GVHD and late complication rates were found to be lower in the group given high CD 34 (+) cell count. When the patients were grouped according to the preparation regimens, statistically significantly more complications were observed at the rate of 78.8% in the patients in the myeloablative regimen group (p=0.005). It was observed that the rate of recurrence of the primary disease, renal complications and neurological complications was higher in the 90-120th days after transplantation. Ocular and GVHD complications were more likely to develop later. It was observed that endocrine complications were encountered equally in both early and late periods. Discussion: It was seen that, late complications were common in patients who underwent allogeneic HSCT and these complications were mostly related to GVHD and GVHD treatment.en_US
dc.identifier.doi10.5505/aot.2022.92668
dc.identifier.endpage115en_US
dc.identifier.issn0304-596X
dc.identifier.issn2148-7669
dc.identifier.issue2en_US
dc.identifier.startpage109en_US
dc.identifier.trdizinid1122821en_US
dc.identifier.urihttps://doi.org/10.5505/aot.2022.92668
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1122821
dc.identifier.urihttps://hdl.handle.net/11616/88390
dc.identifier.volume55en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofACTA ONCOLOGICA TURCICAen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleNon-Infectious Complications in Patients with Allogeneic Hematopoietic Stem Cell Transplantation- Single Center Experience from Eastern Anatoliaen_US
dc.typeArticleen_US

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