Protective effects of resveratrol on spleen and ileum in rats subjected to ischemia-reperfusion

Basit Öğe Kaydı
dc.authoridbay karabulut, aysun/0000-0002-7873-2805
dc.authoridYilmaz, Sezai/0000-0002-8044-0297
dc.authoridÇANKAYA, ÖZLEM/0000-0002-7407-2352
dc.authorwosidbay karabulut, aysun/HJP-0995-2023
dc.authorwosidYilmaz, Sezai/ABI-2323-2020
dc.authorwosidÇANKAYA, ÖZLEM/ABH-9456-2020
dc.contributor.authorKarabulut, AB
dc.contributor.authorKirimlioglu, V
dc.contributor.authorKirimlioglu, H
dc.contributor.authorYilmaz, S
dc.contributor.authorIsik, B
dc.contributor.authorIsikgil, O
dc.date.accessioned2024-08-04T20:15:21Z
dc.date.available2024-08-04T20:15:21Z
dc.date.issued2006
dc.departmentİnönü Üniversitesien_US
dc.description8th Meeting of the Turkish-Transplantation-Society -- JUN 22-24, 2005 -- Ankara, TURKEYen_US
dc.description.abstractResveratrol is as an antioxidant with free radical-scavenging activity and finds its clinical application in the prevention of postischernic tissue injury following solid organ transplantation. This study investigates the effect of Resveratrol on spleen and ileum tissues subjected to hepatic ischemia-reperfusion (I/R) in rats. Twenty-four rats were recruited in the study as follows: group A: I/R (n = 8), group B: I/R + Resveratrol (it = 8), and group C: sham operation (n = 8). After intraperitonealy pretreatment of eight rats with resveratrol (15 mg/kg/d) for 5 days, 16 rats were subjected to 45 minutes of hepatic ischemia followed by 30 minutes reperfusion period. Resveratrol was given 15 minutes prior to ischemia and just before the reperfusion in rats. After reperfusion period all rats were sacrified. Spleen and ileum tissues were examined spectrophotometrically to measure malondialdehyde (MDA), glutathione (GSH), and total nitrite, nitrate as an end product of nitric oxide (NO) levels. Concerning the spleen, statistically significant decrease of GSH and increase of MDA and NO levels were found group A when compared to groups B and C (P = .040, P = .004, and P = .001 group A vs group B; P = .05, P = .003, and P = .001 group A vs group C, respectively). Parallel results were obtained in ileum. A statistically significant decrease in GSH and an increase in MDA and NO levels in group A in respect to group B and group C was obtained (P = .048, P = .034, and P = .00.1 group A vs group B; P = .004, P = .001, and P = .003 group A vs group C, respectively). The result of this study shows that resveratrol has a protective effect on spleen and ileal mitochondrial oxidative stress in rats subjected to I/R.en_US
dc.description.sponsorshipTurkish Transplantat Socen_US
dc.identifier.doi10.1016/j.transproceed.2006.01.017
dc.identifier.endpage377en_US
dc.identifier.issn0041-1345
dc.identifier.issn1873-2623
dc.identifier.issue2en_US
dc.identifier.pmid16549124en_US
dc.identifier.scopus2-s2.0-33645054059en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage375en_US
dc.identifier.urihttps://doi.org/10.1016/j.transproceed.2006.01.017
dc.identifier.urihttps://hdl.handle.net/11616/94318
dc.identifier.volume38en_US
dc.identifier.wosWOS:000236440100008en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofTransplantation Proceedingsen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGlutathione-Peroxidaseen_US
dc.subjectInjuryen_US
dc.subjectInactivationen_US
dc.subjectMelatoninen_US
dc.titleProtective effects of resveratrol on spleen and ileum in rats subjected to ischemia-reperfusionen_US
dc.typeConference Objecten_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu