The determination of oxidative damage in heart tissue of rats caused by ruthenium(II) and gold(I) N-heterocyclic carbene complexes

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dc.authoridDüşünceli, Serpil Demir/0000-0001-8765-4039
dc.authoridCakir, Oguz/0000-0002-8006-2054
dc.authoridCiftci, Osman/0000-0001-5755-3560
dc.authorwosidÇakır, Oğuz/CAF-8360-2022
dc.authorwosidDüşünceli, Serpil Demir/AAA-7160-2021
dc.authorwosidDemir, Serpil/AAI-1740-2019
dc.authorwosidÖzdemir, İlknur/AAA-6216-2021
dc.contributor.authorCiftci, Osman
dc.contributor.authorOzdemir, Ilknur
dc.contributor.authorCakir, Oguz
dc.contributor.authorDemir, Serpil
dc.date.accessioned2024-08-04T20:35:35Z
dc.date.available2024-08-04T20:35:35Z
dc.date.issued2011
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIn the present study, we aimed to determine the oxidative damage in rat heart tissue induced by ruthenium(II)-NHC (Ru) and gold(I)-NHC (Au) complexes which have anticarcinogenic effects and not used clinically yet. For this purpose, 35 Sprague-Dawley ratswere randomly divided into 5 equal groups. In the control group, rats treated with saline, Ru and Au complexes were intraperitoneally given high (10 mg/kg) and low (5 mg/kg) doses as only one administration. The animals were killed, and heart tissues were taken on day 10 of the drug administration for the determination of the biochemical parameters (malondialdehyde, superoxide dismutase, reduced glutathione and catalase levels). It was determined that both Ru and Au complexes treatment significantly caused oxidative damage compared to the control group. Additionally, it was shown that Au treatment causedmore adverse effects than Ru treatment. Also, it was clearly found that the occurred effects were generally determined in a dose-dependent manner. In conclusion, when these compounds synthesized for the treatment of cancer were used, they caused oxidative damage in heart tissue. However, Ru complex could be preferred for cancer treatment in terms of user safety.en_US
dc.description.sponsorshipTUBITAK; TUBITAK (Scientific and Technical Research Council of the Turkish Republic) [109T540]en_US
dc.description.sponsorshipIt is a great pleasure to thank TUBITAK for their financial support during our project.; This study was supported by TUBITAK (Scientific and Technical Research Council of the Turkish Republic) under Grant 109T540.en_US
dc.identifier.doi10.1177/0748233710395993
dc.identifier.endpage741en_US
dc.identifier.issn0748-2337
dc.identifier.issn1477-0393
dc.identifier.issue8en_US
dc.identifier.pmid21427133en_US
dc.identifier.scopus2-s2.0-80054774739en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage735en_US
dc.identifier.urihttps://doi.org/10.1177/0748233710395993
dc.identifier.urihttps://hdl.handle.net/11616/95465
dc.identifier.volume27en_US
dc.identifier.wosWOS:000294229500008en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Incen_US
dc.relation.ispartofToxicology and Industrial Healthen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectRuthenium(II)en_US
dc.subjectgold(I)en_US
dc.subjectoxidative stressen_US
dc.subjectheart tissueen_US
dc.subjectNHC complexesen_US
dc.titleThe determination of oxidative damage in heart tissue of rats caused by ruthenium(II) and gold(I) N-heterocyclic carbene complexesen_US
dc.typeArticleen_US

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