Influence of dihydropyridine calcium antagonist nitrendipine on benzo(a)pyrene-induced oxidative stress

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dc.authoridPolat, Alaadin/0000-0002-6920-3856
dc.authoridPolat, Alaadin/0000-0002-6920-3856
dc.authoridAKTAY, Goknur/0000-0002-1646-8674
dc.authorwosidPolat, Alaadin/AAA-7171-2021
dc.authorwosidPolat, Alaadin/Q-4052-2018
dc.contributor.authorAktay, Goknur
dc.contributor.authorEmre, Memet Hanifi
dc.contributor.authorPolat, Alaadin
dc.date.accessioned2024-08-04T20:35:33Z
dc.date.available2024-08-04T20:35:33Z
dc.date.issued2011
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe aim of this study was to investigate the influence of nitrendipine (NIT), a dihydropyridine derived calcium channel antagonist, on polycyclic aromatic hydrocarbon benzo(a)pyrene (BAP)-induced oxidative stress. Male Sprague Dawley rats (155-220 g) were divided into four groups: Control (corn oil, i.p.); BAP (200 mg/kg, i.p.), BAP + NIT (200 mg/kg, i.p. + 50 mg/kg, i.p.), and NIT (50 mg/kg, i.p.) groups. Twenty-four hours after the injection of BAP, the rats were sacrificed and blood samples, liver, lung, and brain tissues were removed to determine serum alanine transaminase (ALT), aspartate transferase (AST), and gamma-glutamyltransferase (GGT) activities and tissue thiobarbituric acid reactive substances (TBARS), glutathione (GSH), and superoxide dismutase (SOD) levels. BAP significantly elevated serum ALT and TBARS levels in all tissues. However, NIT pre-treatment protected against increasing TBARS levels in lung and brain tissues. In addition, NIT pre-treatment significantly increased SOD levels in lung and liver tissues, as well as GSH levels in the lungs, compared to the BAP group. Thus, in conclusion, further studies are required to confirm the protective effects of calcium channel blockers, especially in liver tissue.en_US
dc.identifier.doi10.1007/s12272-011-0715-x
dc.identifier.endpage1175en_US
dc.identifier.issn0253-6269
dc.identifier.issue7en_US
dc.identifier.pmid21811924en_US
dc.identifier.scopus2-s2.0-80052329464en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage1171en_US
dc.identifier.urihttps://doi.org/10.1007/s12272-011-0715-x
dc.identifier.urihttps://hdl.handle.net/11616/95430
dc.identifier.volume34en_US
dc.identifier.wosWOS:000293460700017en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPharmaceutical Soc Koreaen_US
dc.relation.ispartofArchives of Pharmacal Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntioxidantsen_US
dc.subjectCalcium antagonistsen_US
dc.subjectLipid peroxidationen_US
dc.subjectNitrendipineen_US
dc.subjectOxidative stressen_US
dc.subjectPolycyclic aromatic hydrocarbonsen_US
dc.titleInfluence of dihydropyridine calcium antagonist nitrendipine on benzo(a)pyrene-induced oxidative stressen_US
dc.typeArticleen_US

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