Nutritional characteristic of children with inflammatory bowel disease in the nationwide inflammatory bowel disease registry from the Mediterranean region

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dc.authorscopusid6507620559
dc.authorscopusid57224644818
dc.authorscopusid6603032784
dc.authorscopusid6602686138
dc.authorscopusid8598958500
dc.authorscopusid12647240700
dc.authorscopusid54956571900
dc.contributor.authorKuloglu Z.
dc.contributor.authorÇetin F.
dc.contributor.authorUrgancı N.
dc.contributor.authorÖnal Z.
dc.contributor.authorSarı S.
dc.contributor.authorYüksekkaya H.
dc.contributor.authorÇaltepe G.
dc.date.accessioned2024-08-04T19:59:37Z
dc.date.available2024-08-04T19:59:37Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground/objectives: We analyzed the nationwide pediatric inflammatory bowel disease (PIBD) registry (1998–2016), to evaluate the nutritional status at the time of diagnosis. Subjects/methods: Nine types of nutritional status by the combination of weight-for-length (<2 years)/body mass index (>2 years) and length/height-for-age with three categories (<?2, ?2 to 2, and >2 SD) were described. Malnutrition was defined by WHO criteria. Univariate and multivariate regression analysis was used to identify risk factors for malnutrition. Results: In total, 824 IBD patients (498 Ulcerative colitis (UC); 289 Crohn’s Disease (CD); 37 Indeterminate Colitis (IC); 412 male; the median age 12.5 years) were eligible. The prevalence of eutrophy, wasting/thinness, stunting, overweight, tall stature, concurrent wasting/thinness and stunting, tall stature with overweight, tall stature with wasting/thinness, and short stature with overweight were 67.4%, 14.9%, 6.6%, 3.1%, 3.2%, 3.3%, 1.1%, 0.4%, and 0.1%, respectively. The prevalence of malnutrition was 32.7%, indicating a higher prevalence in CD (p < 0.001). Incidence of overweight was less common in the CD than UC and IC (p < 0.001). Multivariate analysis revealed that age of onset (>10 years), prepubertal stage, severe disease activity, perianal involvement, and high C reactive protein level were independently associated with malnutrition in pediatric IBD. Conclusion: We showed the frequency of nutritional impairment in PIBD. The percentage of overweight subjects was lower than the other studies. The age of onset, disease activity, CRP level, perianal involvement, and pubertal stage were associated with a higher risk for developing malnutrition. Our results also confirmed that CD patients are particularly vulnerable to nutritional impairment. Clinical trial number: ClinicalTrials.gov Identifier: NCT04457518. © 2022, The Author(s), under exclusive licence to Springer Nature Limited.en_US
dc.description.sponsorshipThis research was funded by The Society of Turkish Pediatric Gastroenterology, Hepatology, and Nutrition.en_US
dc.identifier.doi10.1038/s41430-022-01094-6
dc.identifier.endpage1296en_US
dc.identifier.issn0954-3007
dc.identifier.issue9en_US
dc.identifier.pmid35173290en_US
dc.identifier.scopus2-s2.0-85127080460en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1289en_US
dc.identifier.urihttps://doi.org/10.1038/s41430-022-01094-6
dc.identifier.urihttps://hdl.handle.net/11616/90748
dc.identifier.volume76en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Natureen_US
dc.relation.ispartofEuropean Journal of Clinical Nutritionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectC reactive proteinen_US
dc.subjectanemiaen_US
dc.subjectanthropometric parametersen_US
dc.subjectArticleen_US
dc.subjectbody massen_US
dc.subjectbreast feedingen_US
dc.subjectchilden_US
dc.subjectCrohn diseaseen_US
dc.subjectcross-sectional studyen_US
dc.subjectdisease activityen_US
dc.subjecterythrocyte sedimentation rateen_US
dc.subjectfemaleen_US
dc.subjecthumanen_US
dc.subjecthypoalbuminemiaen_US
dc.subjectinflammatory bowel diseaseen_US
dc.subjectleukocytosisen_US
dc.subjectmaleen_US
dc.subjectmalnutritionen_US
dc.subjectmulticenter studyen_US
dc.subjectnutritional assessmenten_US
dc.subjectnutritional statusen_US
dc.subjectobesityen_US
dc.subjectobservational studyen_US
dc.subjectonset ageen_US
dc.subjectpancolitisen_US
dc.subjectpatient selectionen_US
dc.subjectrisk factoren_US
dc.subjectshort statureen_US
dc.subjectsocioeconomicsen_US
dc.subjectSouthern Europeen_US
dc.subjectstuntingen_US
dc.subjecttall statureen_US
dc.subjectthrombocytosisen_US
dc.subjectulcerative colitisen_US
dc.titleNutritional characteristic of children with inflammatory bowel disease in the nationwide inflammatory bowel disease registry from the Mediterranean regionen_US
dc.typeArticleen_US

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