Anti-inflammatory and antioxidative effects of dexpanthenol on nicotine-induced lung injury in rats

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dc.authoridUremis, Muhammed Mehdi/0000-0003-2296-2422
dc.authoridTaslidere, Elif/0000-0003-1723-2556
dc.authorwosidUremis, Muhammed Mehdi/HKP-0531-2023
dc.authorwosidTaslidere, Elif/ABI-8046-2020
dc.contributor.authorAslan, Meral
dc.contributor.authorGuerel, Elif
dc.contributor.authorUeremis, Nuray
dc.contributor.authorUeremis, Muhammed Mehdi
dc.contributor.authorTaslidere, Elif
dc.date.accessioned2024-08-04T20:54:36Z
dc.date.available2024-08-04T20:54:36Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAim Lung inflammation is a consequence of smoking, tobacco use, nicotine addiction, and the accumulation of toxicants in the body. This study aimed to investigate the association between nicotine-induced lung injury and NF-kappa B activation, as well as changes in redox balance. Furthermore, the protective role of Dexpanthenol against this damage was examined. Method A total of 32 male rats were divided into four groups: Control, DEX, Nicotine, and Nicotine + DEX. Nicotine (0.5 mg/kg/day) and Dexpanthenol (500 mg/kg/day) were administered intraperitoneally. Subsequently, the levels of nuclear and cytoplasmic NF-kappa B in lung tissue were analyzed. Inflammation and oxidative stress markers and histopathological evaluations of the lung tissue were conducted. Results Nicotine administration resulted in increased levels of tissue MDA and TOS, as well as decreased levels of GSH-Px, GSH, GST, SOD, and TAS. Additionally, nicotine administration led to elevated nuclear expression of NF-kappa B protein, IL-1 beta, IL-6 proinflammatory cytokine levels, and Galectin-3 levels, which modulate cytokine release. Moreover, histopathological examinations revealed a higher population of diffuse lymphocytes and macrophages, indicating increased lung inflammation. Dexpanthenol administration ameliorated these adverse effects of nicotine and reduced them to levels comparable to the control group. Conclusion Nicotine-induced lung injury promoted oxidative stress and inflammation through modulation of NF-kappa B's nuclear translocation. Dexpanthenol, on the other hand, may serve as a dietary supplement to mitigate lung inflammation caused by smoking and tobacco use.en_US
dc.description.sponsorshipInonu University Scientific Research Project Units [TYL-2021-2508]en_US
dc.description.sponsorshipAcknowledgementsThis study was funded by Inonu University Scientific Research Project Units (Project no: TYL-2021-2508).en_US
dc.identifier.doi10.1007/s13530-023-00184-7
dc.identifier.endpage313en_US
dc.identifier.issn2005-9752
dc.identifier.issn2233-7784
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85166639989en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage303en_US
dc.identifier.urihttps://doi.org/10.1007/s13530-023-00184-7
dc.identifier.urihttps://hdl.handle.net/11616/101499
dc.identifier.volume15en_US
dc.identifier.wosWOS:001041879600001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherKorean Soc Environmental Risk Assessment & Health Scienceen_US
dc.relation.ispartofToxicology and Environmental Health Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNicotineen_US
dc.subjectDexpanthenolen_US
dc.subjectLungen_US
dc.subjectNF-kappa Ben_US
dc.subjectInflammationen_US
dc.subjectOxidative stressen_US
dc.titleAnti-inflammatory and antioxidative effects of dexpanthenol on nicotine-induced lung injury in ratsen_US
dc.typeArticleen_US

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