Changing of antioxidant enzyme activity on the biliary obstructed rats treated with resveratrol
| dc.authorid | 109416 | en_US |
| dc.contributor.author | Çenesiz, Sena | |
| dc.contributor.author | Yarım, G. F. | |
| dc.contributor.author | Bay Karabulut, Aysun | |
| dc.contributor.author | Ara, Cengiz | |
| dc.date.accessioned | 2017-09-08T08:05:37Z | |
| dc.date.available | 2017-09-08T08:05:37Z | |
| dc.date.issued | 2007 | |
| dc.department | İnönü Üniversitesi | en_US |
| dc.description.abstract | The aim of this study was to evaluate the role of antioxidant enzyme activity and nitric oxide levels induced by 28 day biliary obstruction in the rat. A total of 21 young Swiss albino rats were divided in to 3 groups. Bile duct ligations, bile duct ligations plus resveratrol, sham operated. Bile duct ligations plus resveratrol group received 10 mg/kg dose of resveratrol intraperitonealy once daily throughout for 28 days. Liver damage and cholestasis were determined by biochemical examination. SOD, CAT and GSH-PX activity decreased in BDL group compared with shame opareted groups (p < 0.001). NO levels increased in BDL groups compared with shame opareted groups (p < 0.001). SOD, CAT and GSH-PX activity was found higher in BDL+resveratrol treated groups than BDL groups (p < 0.001). In addition this NO levels decreased in BDL+resveratrol treated groups than BDL groups (p < 0.001). In conclusion, it is thought that resveratrol may be used as a protective agent in biliary obstructions; however, further clinical and experimental studies are needed to verify its antioxidative and hepatoprotective effects. | en_US |
| dc.identifier.citation | Çenesiz, S. Yarım, G. F. Bay Karabulut, A. Ara, C. (2007). Changing of antioxidant enzyme activity on the biliary obstructed rats treated with resveratrol. Dtsch Tierarztl Wochenschr. 114(9):345-348. | en_US |
| dc.identifier.endpage | 348 | en_US |
| dc.identifier.issue | 9 | en_US |
| dc.identifier.startpage | 345 | en_US |
| dc.identifier.uri | https://hdl.handle.net/11616/7733 | |
| dc.identifier.volume | 114 | en_US |
| dc.language.iso | en | en_US |
| dc.publisher | Dtsch Tierarztl Wochenschr | en_US |
| dc.relation.ispartof | Dtsch Tierarztl Wochenschr | en_US |
| dc.rights | info:eu-repo/semantics/embargoedAccess | en_US |
| dc.title | Changing of antioxidant enzyme activity on the biliary obstructed rats treated with resveratrol | en_US |
| dc.type | Article | en_US |
