The efficacy of remifentanil combined with either propofol, sevoflurane or desflurane during controlled hypotension

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dc.authorscopusid7003586739
dc.authorscopusid55898201200
dc.authorscopusid7006384185
dc.authorscopusid8932188900
dc.authorscopusid16551644900
dc.authorscopusid7004486274
dc.contributor.authorDemirbilek S.
dc.contributor.authorGülhaş N.
dc.contributor.authorÖztürk E.
dc.contributor.authorBut A.K.
dc.contributor.authorAslan Ü.
dc.contributor.authorErsoy M.Ö.
dc.date.accessioned2024-08-04T20:00:57Z
dc.date.available2024-08-04T20:00:57Z
dc.date.issued2004
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe aim of this study was to compare the effects of a combination of remifentanil with propofol, desflurane or sevoflurane on intraoperative controlled hypotension, quality of the surgical field and recovery characteristics in patients undergoing nose surgery. ASA physical status I, 18-47 yr of age, 54 patients were randomly divided to three groups and received remifentanil 1?g kg-1 as a bolus dose followed by a continuous infusion of 0.25 ?g kg-1 min-1. In propofol group, anesthesia was induced 1.5-2 mg kg-1 of propofol and maintained with a continuous infusion of 100-200 ?g kg-1 min-1. In sevoflurane group, anesthesia was induced with 7% sevoflurane in 100% oxygen, and was maintained with 1-2% sevoflurane and air in oxygen. In desflurane group, anesthesia was induced 1.5-2 mg kg-1 of propofol and maintained with 4-6% desflurane and air in oxygen. The study drug titration was adjusted to keep the systolic blood pressure (SBP) between 80-100 mmHg during surgery. During controlled hypotension, while SBP was significantly lower in desflurane and sevoflurane groups than in propofol group, mean blood pressure (MBP) was significantly lower in sevoflurane group than in other groups (p<0.05). Supplemental hypotensive agent was administered to 2 patients in propofol group and 1 patient in desflurane group. After extubation, MBP and heart rate (HR) significantly increased in propofol group, HR significantly increased in sevoflurane group, SBP, MBP and HR significantly increased in desflurane group according to preinduction values (p<0.05). Estimated blood loss and surgical field score was similar in all three groups. The time to extubation and early recovery was significantly shorter in desflurane group than in sevoflurane and propofol groups (p<0.05). We concluded that since all three anesthetic techniques provided hemodynamic stability and good visualization of the surgical field, they may be used for controlled hypotension management. However, sevoflurane-remifentanil combination may be preferable, because it did not cause any increase in blood pressure after extubation.en_US
dc.identifier.endpage196en_US
dc.identifier.issn1300-0578
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-4344674000en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage191en_US
dc.identifier.urihttps://hdl.handle.net/11616/91139
dc.identifier.volume12en_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.relation.ispartofAnestezi Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectControlled hypotensionen_US
dc.subjectDesfluraneen_US
dc.subjectPropofolen_US
dc.subjectRemifentanilen_US
dc.subjectSevofluraneen_US
dc.titleThe efficacy of remifentanil combined with either propofol, sevoflurane or desflurane during controlled hypotensionen_US
dc.title.alternativekontrollü hipotansiyonda remifentanil ? ile birlikte uygulanan propofol, desfluran ve sevofluranin etkinli?ien_US
dc.typeArticleen_US

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