Comparative effects of several therapatic agents on hepatic damage induced by acute experimental pancreatitis

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dc.authoridEşrefoğlu, Mukaddes/0000-0003-3380-1480
dc.authoridGül, Mehmet/0000-0002-1374-0783
dc.authorwosidEşrefoğlu, Mukaddes/JWA-4590-2024
dc.authorwosidGül, Mehmet/ABI-6336-2020
dc.contributor.authorEsrefoglu, Mukaddes
dc.contributor.authorGul, Mehmet
dc.contributor.authorTuran, Fahri
dc.date.accessioned2024-08-04T20:30:47Z
dc.date.available2024-08-04T20:30:47Z
dc.date.issued2008
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPurpose The prognosis of acute pancreatitis (AP) depends upon the degree of pancreatic necrosis and the intensity of multisystem organ failure. The liver contributes to the systemic manifestations of AP by releasing some cytokines. This study was undertaken to examine comparative effects of melatonin, antioxidant mixture containing L(+)-ascorbic acid and N-acetyl cysteine, pentoxifylline and L-arginine on hepatic damage induced by caerulein-pancreatitis. Results The liver specimens of all groups showed histopathological alterations such as hepatocyte necrosis, intracellular vacuolization, vascular congestion, sinusoidal dilatation and inflammatory infiltration. TEM studies revealed vacuole formation, mitochondrial degeneration, lysosome accumulation and necrosis. The mean histopathological score of the caerulein group was significantly different from that of each treatment group. Conclusion L-Arginine and antioxidant administration be important for reducing hepatic damage induced by AP. Improvement of hepatic damage, in turn, might be beneficial for the prognosis of AP.en_US
dc.identifier.doi10.1007/s10620-007-0007-y
dc.identifier.endpage1310en_US
dc.identifier.issn0163-2116
dc.identifier.issue5en_US
dc.identifier.pmid17934852en_US
dc.identifier.scopus2-s2.0-41949089723en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1303en_US
dc.identifier.urihttps://doi.org/10.1007/s10620-007-0007-y
dc.identifier.urihttps://hdl.handle.net/11616/94507
dc.identifier.volume53en_US
dc.identifier.wosWOS:000254848200021en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofDigestive Diseases and Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectliveren_US
dc.subjectoxidative stressen_US
dc.subjectnitric oxideen_US
dc.subjectmelatoninen_US
dc.subjectpancreatitisen_US
dc.subjectpentoxifyllineen_US
dc.titleComparative effects of several therapatic agents on hepatic damage induced by acute experimental pancreatitisen_US
dc.typeArticleen_US

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