Royal jelly arranges apoptotic and oxidative stress pathways and reduces damage to liver tissues of rats by down-regulation of Bcl-2, GSK3 and NF-?B and up-regulation of caspase and Nrf-2 protein signalling pathways

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dc.authoridGök, Özlem/0000-0001-8521-6369
dc.authoridParlak, Gozde/0000-0002-8982-887X
dc.authoridCan, Muhammed Ismail/0000-0002-0118-2278
dc.authoridAslan, Abdullah/0000-0002-6243-4221
dc.authoridPARLAK, AKIF EVREN/0000-0002-2579-9985
dc.authoridBaspinar, Serpil/0000-0001-9496-2451
dc.authorwosidGök, Özlem/AFV-8223-2022
dc.authorwosidCan, Muhammed İsmail/ABG-8646-2020
dc.authorwosidParlak, Gozde/ISA-6808-2023
dc.authorwosidcan, mi/KDN-4165-2024
dc.authorwosidAslan, Abdullah/C-9523-2016
dc.authorwosidPARLAK, AKIF EVREN/V-8579-2018
dc.authorwosidBaspinar, Serpil/V-8526-2018
dc.contributor.authorAslan, Abdullah
dc.contributor.authorGok, Ozlem
dc.contributor.authorBeyaz, Seda
dc.contributor.authorParlak, Gozde
dc.contributor.authorCan, Muhammed Ismail
dc.contributor.authorGundogdu, Ramazan
dc.contributor.authorBaspinar, Serpil
dc.date.accessioned2024-08-04T20:53:17Z
dc.date.available2024-08-04T20:53:17Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIntroduction: Royal jelly (RJ) from the honey bee, Apis mellifera, is a traditional product that is widely used as a food supplement to support the medical treatment of various diseases. Material and methods: Our study continued for 8 weeks. 42 Wistar albino (8 weeks old) male rats were used in the study. The study included 6 groups; Group 1: Control group (fed with standard diet), Group 2: RJ (100 mg/kg, bw), Group 3: F-50 (50 mg/kg, bw), group 4: F-100 (100 mg/kg, bw) group 5: F-50 (50 mg/kg, bw) + RJ (100 mg/kg, bw) Group 6: F-100 (100 mg/kg, bw) + RJ (100 mg/kg, bw). Malondialdehyde (MDA), catalase (CAT) and glutathione (GSH) activities in liver tissue were determined by spectrophotometer. Liver tissue samples were examined histopathologically and various protein levels were determined by Western blotting technique. Results: RJ caused a significant decrease in MDA level, Bcl-2, GSK3 and NF-kappa B protein expression levels, whereas induced a significant increase in GSH level, CAT activities and Bax, BDNF, caspase-6, caspase-3, Nrf-2 protein expression levels. Conclusion: Our findings suggest RJ to be used as a hepatoprotective agent in the clinic to modulate the toxic effects of fluoride and other chemicals in the future.en_US
dc.description.sponsorshipFirat University Research Projects Unit (FUBAP); [FF.19.16]en_US
dc.description.sponsorshipThis study was supported by Firat University Research Projects Unit (FUBAP) [Project No: FF.19.16].en_US
dc.identifier.doi10.1080/1354750X.2022.2159526
dc.identifier.endpage226en_US
dc.identifier.issn1354-750X
dc.identifier.issn1366-5804
dc.identifier.issue2en_US
dc.identifier.pmid36520139en_US
dc.identifier.scopus2-s2.0-85145324438en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage217en_US
dc.identifier.urihttps://doi.org/10.1080/1354750X.2022.2159526
dc.identifier.urihttps://hdl.handle.net/11616/101089
dc.identifier.volume28en_US
dc.identifier.wosWOS:000904862900001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofBiomarkersen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFluorideen_US
dc.subjectliver damageen_US
dc.subjectNF-kappa Ben_US
dc.subjectNrf-2en_US
dc.subjectoxidative stressen_US
dc.subjectroyal jellyen_US
dc.titleRoyal jelly arranges apoptotic and oxidative stress pathways and reduces damage to liver tissues of rats by down-regulation of Bcl-2, GSK3 and NF-?B and up-regulation of caspase and Nrf-2 protein signalling pathwaysen_US
dc.typeArticleen_US

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