The regulatory role of dietary ?-3 essential fatty acids on oxidant/antioxidant balance in rat hippocampus

Basit Öğe Kaydı
dc.contributor.authorSarsimaz, M
dc.contributor.authorSongur, A
dc.contributor.authorKus, I
dc.contributor.authorOzyurt, B
dc.contributor.authorGulec, M
dc.contributor.authorSogut, S
dc.contributor.authorIlhan, A
dc.date.accessioned2024-08-04T20:13:29Z
dc.date.available2024-08-04T20:13:29Z
dc.date.issued2003
dc.departmentİnönü Üniversitesien_US
dc.description.abstractOmega-3 essential fatty acids (omega-3 EFA) contains eicosapentaenoic acid and docosahexaenoic acid (DHA). DHA is one of the building structures of membrane phospholipids of brain and necessary for continuity of neuronal functions. omega-3 EFA has been suggested to be protective against neuropsychiatric disorders including schizophrenia. This study proposed to assess the changes in superoxide dismutase (SOD), xanthine oxidase (XO), malondialdehyde (MDA), and nitric oxide (NO) in the hippocampus of rats fed with omega-3 EFA diet (0.4 g/kg/day) for 30 days. Eight control rats and nine rats fed with omega-3 EFA were decapitated under ether anesthesia, and hippocampus was removed immediately. Rats treated with omega-3 EFA had significantly lower XO activity (p<0.002) and NO level (p<0.0001) whereas higher SOD activity (p<0.002) and MDA levels (p<0.019) than the control rats. These results suggest that the dietary omega-3 EFA may act on the oxidant/antioxidant parameters in hippocampus. On the other hand, although the mechanism is not clear, omega-3 EFA may enhance one of the most important antioxidant enzymes, SOD. Further studies are needed to clarify the molecular mechanism involved and the therapeutic implication of omega-3 EFA in animal psychosis models and clinical studies.en_US
dc.identifier.doi10.1002/nrc.10087
dc.identifier.endpage123en_US
dc.identifier.issn0893-6609
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-0242443733en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage114en_US
dc.identifier.urihttps://doi.org/10.1002/nrc.10087
dc.identifier.urihttps://hdl.handle.net/11616/93650
dc.identifier.volume33en_US
dc.identifier.wosWOS:000186378700005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherJohn Wiley & Sons Ltden_US
dc.relation.ispartofNeuroscience Research Communicationsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectomega-3 essential fatty acidsen_US
dc.subjectsuperoxide dismutaseen_US
dc.subjectxanthine oxidaseen_US
dc.subjectlipid peroxidationen_US
dc.subjectnitric oxideen_US
dc.subjectschizophrenia therapyen_US
dc.titleThe regulatory role of dietary ?-3 essential fatty acids on oxidant/antioxidant balance in rat hippocampusen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu