The contradictory effects of nitric oxide in caerulein-induced acute pancreatitis in rats

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dc.authoridGül, Mehmet/0000-0002-1374-0783
dc.authoridAteş, Burhan/0000-0001-6080-229X
dc.authoridEşrefoğlu, Mukaddes/0000-0003-3380-1480;
dc.authorwosidGül, Mehmet/ABI-6336-2020
dc.authorwosidAteş, Burhan/AAA-3730-2021
dc.authorwosidEşrefoğlu, Mukaddes/JWA-4590-2024
dc.authorwosidOzturk, Feral/A-2678-2016
dc.contributor.authorOzturk, Feral
dc.contributor.authorGul, Mehmet
dc.contributor.authorEsrefoglu, Mukaddes
dc.contributor.authorAtes, Burhan
dc.date.accessioned2024-08-04T20:30:56Z
dc.date.available2024-08-04T20:30:56Z
dc.date.issued2008
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThis study was planned to observe the effects of nitric oxide synthesis on the antioxidative defense enzymes and pancreatic tissue histology in caerulein-induced acute pancreatitis. Acute pancreatitis was induced by intraperitoneal injections of 50 mu g/kg caerulein, L-arginine used for NO induction and N-omega-nitro-L-arginine methyl ester (L-NAME) used for NO inhibition. In the caerulein group acinar cell degeneration, interstitial inflammation, oedema and haemorrhage were detected. Pancreatic damage scores were decreased with both NO induction and inhibition (p<0.05). MDA, GSH-Px, CAT, GSH and SOD activities were significantly changed in the caerulein group and indicated increased oxidative stress. Both NO induction and inhibition decreased this oxidative stress. It is concluded that both nitric oxide induction and inhibition ameliorated caerulein-induced acute pancreatitis. The findings indicate that a certain amount of NO production has beneficial effects in experimental acute pancreatitis, but uncontrolled over-production of NO may be detrimental.en_US
dc.identifier.doi10.1080/10715760801930730
dc.identifier.endpage296en_US
dc.identifier.issn1071-5762
dc.identifier.issn1029-2470
dc.identifier.issue4en_US
dc.identifier.pmid18404527en_US
dc.identifier.scopus2-s2.0-48849089848en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage289en_US
dc.identifier.urihttps://doi.org/10.1080/10715760801930730
dc.identifier.urihttps://hdl.handle.net/11616/94614
dc.identifier.volume42en_US
dc.identifier.wosWOS:000254869700001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofFree Radical Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectacute pancreatitisen_US
dc.subjectnitric oxideen_US
dc.subjectoxidative stressen_US
dc.subjectlighten_US
dc.subjectelectron microscopyen_US
dc.titleThe contradictory effects of nitric oxide in caerulein-induced acute pancreatitis in ratsen_US
dc.typeArticleen_US

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