MR spectroscopy in the differential diagnosis of focal brain lesions in neurofibromatosis type 1 patients

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dc.authorscopusid7006266098
dc.authorscopusid7003405757
dc.authorscopusid6701859321
dc.authorscopusid59026766300
dc.authorscopusid6603917376
dc.authorscopusid6507393726
dc.authorscopusid36939977500
dc.contributor.authorAlkan A.
dc.contributor.authorKutlu R.
dc.contributor.authorSigirci A.
dc.contributor.authorBaysal T.
dc.contributor.authorAltinok T.
dc.contributor.authorDusak A.
dc.contributor.authorSaraç K.
dc.date.accessioned2024-08-04T20:01:01Z
dc.date.available2024-08-04T20:01:01Z
dc.date.issued2003
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPURPOSE: To determine the role of MR spectroscopy in the differential diagnosis of focal brain lesions in neurofibromatosis type 1. MATERIALS AND METHODS: Fifteen patients with neurofibromatosis type 1 were evaluated by routine MRI and single voxel MR spectroscopy (TE: 31). The posterior parietal white matter of 20 age-matched healthy volunteers constituted the control group. NAA/Cr, Cho/Cr and MI/Cr ratios were calculated and compared with the control group. RESULTS: A total of 58 focal brain lesions were detected by MR imaging. When patients with hamartomas and gliomas were compared with the control group, a decrease in the NAA/Cr ratio, and a significant increase in Cho/Cr and MI/Cr ratios were found. The decrease in the NAA/Cr ratio and the increase in Cho/Cr and MI/Cr ratios of gliomas were significant when compared with hamartomas. With MRI and MR spectroscopy findings, 52 hamartomas and 6 gliomas were detected. CONCLUSION: Since MR spectroscopy has the ability to detect cellular metabolic changes, it could provide additional information to MR imaging about the differential diagnosis and treatment planning of focal parenchymal lesions in neurofibromatosis type 1.en_US
dc.identifier.endpage170en_US
dc.identifier.issn1300-4360
dc.identifier.issue2en_US
dc.identifier.pmid14661483en_US
dc.identifier.scopus2-s2.0-1542779959en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage166en_US
dc.identifier.urihttps://hdl.handle.net/11616/91202
dc.identifier.volume9en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isotren_US
dc.relation.ispartofTanisal ve girişimsel radyoloji : Tibbi Görüntüleme ve Girişimsel Radyoloji Dernegi yayin organien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectadolescenten_US
dc.subjectadulten_US
dc.subjectarticleen_US
dc.subjectbrain tumoren_US
dc.subjectcase control studyen_US
dc.subjectchilden_US
dc.subjectdifferential diagnosisen_US
dc.subjectevaluationen_US
dc.subjectfemaleen_US
dc.subjecthumanen_US
dc.subjectmaleen_US
dc.subjectmiddle ageden_US
dc.subjectneurofibromatosisen_US
dc.subjectnuclear magnetic resonance imagingen_US
dc.subjectpathologyen_US
dc.subjectprediction and forecastingen_US
dc.subjectpreschool childen_US
dc.subjectAdolescenten_US
dc.subjectAdulten_US
dc.subjectBrain Neoplasmsen_US
dc.subjectCase-Control Studiesen_US
dc.subjectChilden_US
dc.subjectChild, Preschoolen_US
dc.subjectDiagnosis, Differentialen_US
dc.subjectFemaleen_US
dc.subjectHumansen_US
dc.subjectMagnetic Resonance Imagingen_US
dc.subjectMaleen_US
dc.subjectMiddle Ageden_US
dc.subjectNeurofibromatosis 1en_US
dc.subjectPredictive Value of Testsen_US
dc.titleMR spectroscopy in the differential diagnosis of focal brain lesions in neurofibromatosis type 1 patientsen_US
dc.title.alternativeTip 1 nörofibromatozisli hastalarda fokal beyin lezyonlarinin ayirici tanisinda MR spektroskopi.en_US
dc.typeArticleen_US

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