Effects of Molsidomine on Retinopathy and Oxidative Stress Induced by Radiotheraphy in Rat Eyes

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dc.authoridPolat, Nihat/0000-0002-1735-1363
dc.authoridParlakpinar, Hakan/0000-0001-9497-3468
dc.authoridParlakpınar, Hakan/0000-0001-9497-3468
dc.authoridVardı, Nigar/0000-0003-0576-1696
dc.authoridÖzer, Murat atabey/0000-0003-1807-6911
dc.authoridTanbek, Kevser/0000-0003-2099-2273
dc.authoridPolat, Alaadin/0000-0002-6920-3856
dc.authorwosidEkici, Kemal/AFJ-9488-2022
dc.authorwosidPolat, Nihat/ABI-7316-2020
dc.authorwosidParlakpinar, Hakan/V-6637-2019
dc.authorwosidParlakpınar, Hakan/T-6517-2018
dc.authorwosidEkici, Kemal/AAF-6505-2022
dc.authorwosidVardı, Nigar/C-9549-2018
dc.authorwosidÖzer, Murat atabey/ISV-0275-2023
dc.contributor.authorOzer, Murat Atabey
dc.contributor.authorPolat, Nihat
dc.contributor.authorOzen, Serkan
dc.contributor.authorParlakpinar, Hakan
dc.contributor.authorEkici, Kemal
dc.contributor.authorPolat, Alaaddin
dc.contributor.authorVardi, Nigar
dc.date.accessioned2024-08-04T20:42:51Z
dc.date.available2024-08-04T20:42:51Z
dc.date.issued2017
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPurpose: To determine the role of Molsidomine in preventing radiation-induced retinopathy after head and neck region irradiation of rats with a single radiation dose of 15 Gy. Materials and Methods: Male Wistar albino rats were randomly grouped into five as follows: (1) control group rats, which were applied through an intraperitoneal (i.p.) vehicle without radiotherapy (RT); (2) RT group rats received a single dose of 15 Gy irradiation and after daily 0.1 ml vehicle i.p. for 5 consecutive days; (3) molsidomine (MOL) group rats were treated for 5 consecutive days by i.p. with 4 mg/kg/day MOL; (4) irradiation plus MOL group (RT+MOL) rats received irradiation and after 10 days single daily i.p. dose of MOL for 5 consecutive days; and (5) MOL+RT group rats were treated for 5 consecutive days by i.p. with MOL before RT. At the end of the work the rats were sacrificed under high-dose anesthesia on the 16(th) day and then eye tissues were taken for histopathological, immunohistochemical (caspase-3), and biochemical analyses (superoxide dismutase [SOD], glutathione peroxidase [GSH], and malondialdehyde [MDA]). Results: RT significantly decreased both the content of GSH and the activity of SOD, and significantly increased the production of MDA level in the rat eyes. MOL treatment significantly increased the SOD and GSH levels and significantly decreased the MDA production (p < 0.0001). In addition, RT significantly increased the number of ganglion cells (GCs; p = 0.001), whereas especially pretreatment with MOL improved (p = 0.013). RT led to significant retinopathy formation, and MOL therapy protected the retina from radiation-induced retinopathy (p < 0.0001). Conclusions: We suggest that MOL is a powerful antioxidant and free radical scavenger that prevents the rat eyes from radiation-induced retinopathy and oxidative stress.en_US
dc.identifier.doi10.1080/02713683.2016.1238943
dc.identifier.endpage809en_US
dc.identifier.issn0271-3683
dc.identifier.issn1460-2202
dc.identifier.issue5en_US
dc.identifier.pmid27897441en_US
dc.identifier.scopus2-s2.0-84999791791en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage803en_US
dc.identifier.urihttps://doi.org/10.1080/02713683.2016.1238943
dc.identifier.urihttps://hdl.handle.net/11616/97604
dc.identifier.volume42en_US
dc.identifier.wosWOS:000400977100023en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofCurrent Eye Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntioxidanten_US
dc.subjectapoptosisen_US
dc.subjectionizing radiationen_US
dc.subjectmolsidomineen_US
dc.subjectoxidative stressen_US
dc.titleEffects of Molsidomine on Retinopathy and Oxidative Stress Induced by Radiotheraphy in Rat Eyesen_US
dc.typeArticleen_US

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