Clinical features and the role of magnetic resonance imaging in pediatric patients with intracranial hypertension

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dc.authoridKılıç, Betül/0000-0003-0884-2635
dc.authorwosidKılıç, Betül/ABS-2287-2022
dc.contributor.authorKilic, Betul
dc.contributor.authorGungor, Serdal
dc.date.accessioned2024-08-04T20:48:44Z
dc.date.available2024-08-04T20:48:44Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIncreased intracranial hypertension (IIH) is a defined clinical condition; however, an unsolved pathophysiologic background usually creates problems in its diagnosis and proper approach. The aim of this study was to emphasize the clinical conditions and brain magnetic resonce imaging (MRI) clues of pediatric patients, especially this clinical entity with high morbidity. Here, we review the etiology, clinical presentation, brain MRI findings, and prognosis of IIH in children. The symptoms' onset age ranged from 9 months to 16 years. Headache (81%), vomiting (37%), and diplopia (33.3%) were the most frequent symptoms. The most common etiologic factors were found to be obesity and dural venous sinus thrombosis. Cerebrospinal fluid (CSF) opening pressure had mean a mean value of 615.2 +/- 248 mm H2O. A significant relationship was found between visual field impairment and height of CSF pressure (p < 0.001). Optic nerve sheath enlargement (88.8%) and optic nerve tortuosity (85.1%) were found as the most common brain MRI findings. Slit-like ventricle (37%), venous sinus thrombosis (29.6%), posterior globe sclera flattening (29.6%), empty sella (25.9%), and intraocular protrusion of the optic nerve (14.8%) were the other findings. A significant relationship was found between CSF opening pressure and the presence of optic nerve tortuosity (p = 0.002), and distension of the optic nerve sheath (p = 0.006). All patients received acetazolamide, only one patient underwent lumboperitoneal shunt, and only one received steroids. In children, IIH can present with different etiologies and symptoms. Brain MRI provides crucial clues in diagnosis. Urgent diagnosis and treatment planning are required to protect vision functions.en_US
dc.identifier.doi10.1007/s13760-020-01415-1
dc.identifier.endpage1573en_US
dc.identifier.issn0300-9009
dc.identifier.issn2240-2993
dc.identifier.issue6en_US
dc.identifier.pmid32666506en_US
dc.identifier.scopus2-s2.0-85087866200en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1567en_US
dc.identifier.urihttps://doi.org/10.1007/s13760-020-01415-1
dc.identifier.urihttps://hdl.handle.net/11616/99413
dc.identifier.volume121en_US
dc.identifier.wosWOS:000548480900002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofActa Neurologica Belgicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectIntracranial hypertensionen_US
dc.subjectHeadacheen_US
dc.subjectChildrenen_US
dc.subjectBrain MRIen_US
dc.subjectVision functionsen_US
dc.titleClinical features and the role of magnetic resonance imaging in pediatric patients with intracranial hypertensionen_US
dc.typeArticleen_US

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