Silyl-functionalised silver rhodium and iridium N-heterocyclic carbene complexes with promising cytotoxicity and antimicrobial potential

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dc.authoridTekin, Suat/0000-0002-2757-1802
dc.authoridSandal, Suleyman/0000-0002-8916-3329
dc.authoridKeskin, Tuba/0000-0002-9212-4021
dc.authoridGünal, Selami/0000-0002-4752-5176
dc.authoridÖzdemir, Namık/0000-0003-3371-9874
dc.authorwosidTekin, Suat/KEI-2266-2024
dc.authorwosidSandal, Suleyman/AAA-6388-2021
dc.authorwosidKeskin, Tuba/AGX-8609-2022
dc.authorwosidGünal, Selami/AAA-7246-2021
dc.authorwosidÖzdemir, Namık/J-6434-2015
dc.contributor.authorKaratas, Mert Olgun
dc.contributor.authorKeskin, Tuba
dc.contributor.authorOzdemir, Namik
dc.contributor.authorKucukbay, Hasan
dc.contributor.authorTekin, Suat
dc.contributor.authorMansur, Ahmet
dc.contributor.authorGunal, Selami
dc.date.accessioned2024-08-04T20:53:04Z
dc.date.available2024-08-04T20:53:04Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIn the present study, we have synthesized Ag, Rh, and Ir complexes of a silyl-substituted NHC ligand in order to investigate their biological properties. Firstly, Ag-NHC (2) complex was synthesized by the interaction of Ag2O with benzimidazolium iodide (1). Rh-(3) and Ir-NHC (4) complexes were synthesized by the transmetalation reaction between Ag-NHC and [M(cod)Cl]2 (M = Rh or Ir) dimers. The complexes were characterised by NMR spectroscopy and elemental analyses, and crystal structures of Rh-and Ir-NHC (3 and 4) were also reported. The cytotoxic effects of the complexes were tested on four human cancer cell lines and the antimicrobial activities of the complexes were tested against a panel of nine pathogenic microorganisms. The complexes performed com-parable or better activity than standards, cisplatin and AgNO3.en_US
dc.identifier.doi10.1016/j.inoche.2022.110080
dc.identifier.issn1387-7003
dc.identifier.issn1879-0259
dc.identifier.scopus2-s2.0-85140065714en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.inoche.2022.110080
dc.identifier.urihttps://hdl.handle.net/11616/100948
dc.identifier.volume146en_US
dc.identifier.wosWOS:000874693200003en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofInorganic Chemistry Communicationsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectN -heterocyclic carbeneen_US
dc.subjectSilveren_US
dc.subjectRhodiumen_US
dc.subjectIridiumen_US
dc.subjectCytotoxicityen_US
dc.subjectAntimicrobialen_US
dc.titleSilyl-functionalised silver rhodium and iridium N-heterocyclic carbene complexes with promising cytotoxicity and antimicrobial potentialen_US
dc.typeArticleen_US

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