The Postoperative Analgesic Effects of Celecoxib and Rofecoxib in Total Abdominal Hysterectomy

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dc.authorscopusid34569135700
dc.authorscopusid6603851680
dc.authorscopusid7003586739
dc.authorscopusid8098620700
dc.authorscopusid6506222899
dc.contributor.authorDurmuş M.
dc.contributor.authorKöro?lu A.
dc.contributor.authorDemirbilek S.
dc.contributor.authorÖzgül Ü.
dc.contributor.authorÖzcan Ersoy M.
dc.date.accessioned2024-08-04T20:02:07Z
dc.date.available2024-08-04T20:02:07Z
dc.date.issued2003
dc.departmentİnönü Üniversitesien_US
dc.description.abstractCelecoxib and rofecoxib that have been used in our country for treatment of osteoartritis and rheumatoid artritis are two COX-2 selective inhibitor non-steroidal antiinflammatory drugs. The aim of this study is to investigate postoperative analgesic and morphine sparing effects of single dose celecoxib or rofecoxib which were given before surgery in patients undergoing total abdominal hysterectomy. After obtaining approval from Ethics Committee, we studied 60 ASA I-II females undergoing total elective abdominal hysterectomy in a randomised, placebo controlled, double blind study. Patients were divided into 200 mg celecoxib (Group I, n=20), 50 mg rofecoxib (Group II, n=20) and placebo (Group III, n=20) groups. Anaesthesia was induced with 1.5 ?g kg -1 fentanyl, 4-6 mg kg-1 thiopental and 0.1 mg kg -1 vecuronyum. Morphine consumption, VAS scores at rest, on movement and on coughing and degree of sedation were evaluated during postoperative 2nd, 4th, 8th, 12th, and 24th h. Total morphine consumption was lesser in Group II at 8th h compared to Group III and at 12th and 24th h compared to Group I and III (p<0.05). VAS scores at rest, on coughing in Group I and II were significantly decreased during the first 24 h. There are no statistically significant differences between three groups regarding adverse effects. Although both celecoxib and rofecoxib produced a significant decrease in morphine consumption and VAS scores at rest, on movement and on coughing, we concluded that rofecoxib could produce better analgesia in early postoperative period and could decrease morphine consumption after 12th h with its long term effect.en_US
dc.identifier.endpage367en_US
dc.identifier.issn1304-0871
dc.identifier.issue7en_US
dc.identifier.scopus2-s2.0-0142074190en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage363en_US
dc.identifier.urihttps://hdl.handle.net/11616/91439
dc.identifier.volume31en_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.relation.ispartofTurk Anesteziyoloji ve Reanimasyon Dernegi Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnalgesiaen_US
dc.subjectCelecoxiben_US
dc.subjectNon-opioid analgesicsen_US
dc.subjectPostoperativeen_US
dc.subjectRofecoxiben_US
dc.titleThe Postoperative Analgesic Effects of Celecoxib and Rofecoxib in Total Abdominal Hysterectomyen_US
dc.title.alternativeTotal Abdominal Histerektomide Rofekoksib ve Selekoksibin Postoperatif Analjezik Etkinligien_US
dc.typeArticleen_US

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