Postoperative changes in serum cytokines profile and nitric oxide levels in patients with cystic echinococcosis

Basit Öğe Kaydı
dc.authoridDURMAZ, RIZA/0000-0001-6561-778X
dc.authorwosidDURMAZ, Rıza/HJH-4918-2023
dc.contributor.authorRefik, M
dc.contributor.authorMehmet, N
dc.contributor.authorDurmaz, R
dc.date.accessioned2024-08-04T20:14:59Z
dc.date.available2024-08-04T20:14:59Z
dc.date.issued2005
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe aim of the present study was to examine serum cytokines and nitric oxide (NO) levels in patients with cystic echinococcosis (CE). 28 patients with CE were studied and all underwent surgery. Serum levels of tumour necrosis factor-alpha (TNF-alpha), interleukin IL-1 beta, receptor of soluble IL-2R (sIL-2R), IL-6, IL-8, nitrate/nitrite, and C-reactive protein (CRP) were determined before and after induction of treatment. Data were compared with those obtained from 28 healthy volunteers. IL-6 was elevated in all CE patients (100 %). IL-8 was increased in 11/28 (39.3 %). Increased levels of IL-2R and TNF-alpha were found in a limited number of them particularly those showing cysts in the central area of the liver (5/28, 6/28). IL-1 beta level was not elevated in any patient except in secondary severe CE. CRP and nitrate/nitrite levels were also increased. A positive correlation between CRP and IL-6 (r = 0.74; p < 0.001) was found confirming the link between inflammation due to CE and activation of monocytes. All patients completely recovered and the levels of the studied parameters reverted to normal levels except one patient in whom severe recurrent disease occurred two years after the first operation. These results suggest that there are different immunoregulatory events and cytokines response during CE and may be in part related to slight monocytosis and in part to Th2 activation. IL-6, NO and CRP were unambiguously involved in the host parasite interaction and therefore may be useful markers in monitoring CE management and evaluating surgical stress.en_US
dc.identifier.doi10.1051/parasite/2005123265
dc.identifier.endpage269en_US
dc.identifier.issn1252-607X
dc.identifier.issn1776-1042
dc.identifier.issue3en_US
dc.identifier.pmid16218215en_US
dc.identifier.scopus2-s2.0-24744457308en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage265en_US
dc.identifier.urihttps://doi.org/10.1051/parasite/2005123265
dc.identifier.urihttps://hdl.handle.net/11616/94094
dc.identifier.volume12en_US
dc.identifier.wosWOS:000232364300010en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherEdp Sciences S Aen_US
dc.relation.ispartofParasiteen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectcystic echinococcosisen_US
dc.subjectIL-6en_US
dc.subjectCRPen_US
dc.subjectnitrate/nitriteen_US
dc.titlePostoperative changes in serum cytokines profile and nitric oxide levels in patients with cystic echinococcosisen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu