The effects of erdosteine on the activities of some metabolic enzymes during cisplatin-induced nephrotoxicity in rats

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dc.authoridOZYURT, Huseyin/0000-0003-2327-4082
dc.authoridGergerlioglu, Hasan Serdar/0000-0002-8836-0726
dc.authoridgergerlioglu, hasan serdar/0000-0002-8836-0726
dc.authorwosidOZYURT, Huseyin/N-4351-2015
dc.authorwosidGergerlioglu, Hasan Serdar/GYQ-5617-2022
dc.authorwosidgergerlioglu, hasan serdar/AAG-8348-2021
dc.contributor.authorYilmaz, HR
dc.contributor.authorIraz, M
dc.contributor.authorSogut, S
dc.contributor.authorOzyurt, H
dc.contributor.authorYildirim, Z
dc.contributor.authorAkyol, O
dc.contributor.authorGergerlioglu, S
dc.date.accessioned2024-08-04T20:15:11Z
dc.date.available2024-08-04T20:15:11Z
dc.date.issued2004
dc.departmentİnönü Üniversitesien_US
dc.description.abstractCisplatin is one of the widely used chemothrapeutic agents. One of the major side effects of the drug is renal toxicity. The aims of the presented study was (1) to investigate the effect of cisplatin on some renal metabolic enzyme activities such as hexokinase (HK), glucose-6-phosphate dehydrogenase (G6PD), lactate dehydrogenase (LDH), and malate dehydrogenase (MDH) in an experimental model of acute renal failure and (2) to examine the protective role of erdosteine, an expectorant agent which has also antioxidant properties on cisplatin-induced nephrotoxicity and the enzyme activities mentioned above. Female Wistar albino rats were divided into three groups: sham operation group (n = 6). cisplatin group (n = 9), erdostein + cisplatin group (n = 8). All the chemicals used were applied intraperitoneally. Hexokinase, G6PD, LDH, and MDH activities were determined in the kidney supernatant at the end of the surgical procedures. Spectrophotometric methods were used to determine the activities of above-mentioned enzymes in the kidney tissue. Hexokinase and G6PD activities were found to be increased in cisplatin group compared to control group. G6PD activities were found to be decreased in erdosteine + cisplatin group compared to cisplatin group. There were minimal changes in LDH and MDH activities of the two study groups compared with the control group. The results obtained suggested that the glucose metabolizing metabolic pathways of renal tissue were partially affected from cisplatin toxicity and erdosteine have some protective effects on these enzyme activities. (C) 2004 Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.phrs.2004.03.003
dc.identifier.endpage290en_US
dc.identifier.issn1043-6618
dc.identifier.issue3en_US
dc.identifier.pmid15225672en_US
dc.identifier.scopus2-s2.0-3042545587en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage287en_US
dc.identifier.urihttps://doi.org/10.1016/j.phrs.2004.03.003
dc.identifier.urihttps://hdl.handle.net/11616/94215
dc.identifier.volume50en_US
dc.identifier.wosWOS:000223670900011en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAcademic Press Ltd- Elsevier Science Ltden_US
dc.relation.ispartofPharmacological Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjecterdosteineen_US
dc.subjectcisplatinen_US
dc.subjecthexokinaseen_US
dc.subjectglucose-6-phosphate dehydrogenaseen_US
dc.subjectlactate dehydrogenaseen_US
dc.subjectmalate dehydrogenaseen_US
dc.subjectkidneyen_US
dc.titleThe effects of erdosteine on the activities of some metabolic enzymes during cisplatin-induced nephrotoxicity in ratsen_US
dc.typeArticleen_US

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