Biomimetic approach to tunable adhesion of polyurethane adhesives through Fe3+ crosslinking and hydrophobic tween units with balance of adhesion/cohesion forces

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dc.authoridBALCIOGLU, Sevgi/0000-0003-0724-4772
dc.authoridOzhan, Onural/0000-0001-9018-7849
dc.authoridAteş, Burhan/0000-0001-6080-229X
dc.authoridKeleştemur, Ünzile/0000-0003-4531-6378
dc.authoridBALCIOGLU, Sevgi/0000-0003-0724-4772
dc.authoridKoytepe, Suleyman/0000-0002-4788-278X
dc.authorwosidBALCIOGLU, Sevgi/W-5874-2018
dc.authorwosidKöytepe, Süleyman/AAA-4168-2021
dc.authorwosidOzhan, Onural/AAE-2356-2020
dc.authorwosidAteş, Burhan/AAA-3730-2021
dc.authorwosidKeleştemur, Ünzile/A-4190-2018
dc.authorwosidBALCIOGLU, Sevgi/O-3576-2015
dc.contributor.authorAtes, Burhan
dc.contributor.authorKoytepe, Suleyman
dc.contributor.authorBalcioglu, Sevgi
dc.contributor.authorKaraaslan, Merve Goksin
dc.contributor.authorKelestemur, Unzile
dc.contributor.authorGulgen, Selam
dc.contributor.authorOzhan, Onural
dc.date.accessioned2024-08-04T20:46:00Z
dc.date.available2024-08-04T20:46:00Z
dc.date.issued2019
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBiocompatible adhesives have some limitations such as weak adhesion and low flexibility. To overcome these limitations, we described multiple strategies to provide strong adhesion and high flexibility through Tweens, chlorogenic acid (CLA) and polyethylene glycol (PEG) by reducing excessive interaction between tissue and the adhesive. We synthesized polyurethane-based adhesives using aliphatic 4,4'-methylenebis(cyclohexyl isocyanate) (HMDI), PEG, CLA and Tween units. Hydrophobic side chains in polymer resulted in lower Tg (- 36.95-30.36 degrees C) which indicated more flexibility. The highest adhesion strengths were found as almost 346 kPa for bare polyurethane and 492 kPa for chelated polymer (PU-T40-CLA-15% (5% Tween 40, 15% chlorogenic acid and 80% PEG 200 containing polymer)) with FeCl3. The addition of Tween units provided more stable structure to polymers which proved with in vitro erosion studies. Relatively low erosion values were seen as 5.7, 5.6 and 8.2% in PU-T40-CLA-5% (15% Tween 40, 5% chlorogenic acid and 80% PEG 200 containing polymer), PU-T40-CLA-10% (10% Tween 40, 10% chlorogenic acid and 80% PEG 200 containing polymer), and PU-T40-CLA-15% (5% Tween 40, 15% chlorogenic acid and 80% PEG 200 containing polymer), respectively. In vitro biocompatibility results showed high cell viability in PU-T40-15% as more than 100%. Overall, our findings indicated that these material designs (PU-T-CLAs) provided to overcome the significant challenges of tissue adhesives by improving the flexible character and adhesive strength of the adhesives.en_US
dc.description.sponsorshipScientific and Technical Research Council of Turkey (TUBITAK) [KBAG-114Z591]en_US
dc.description.sponsorshipThis research was supported by the grants of The Scientific and Technical Research Council of Turkey (TUBITAK) with the project number of KBAG-114Z591. We also thank Cihan Ekici for his experimental contributions.en_US
dc.identifier.doi10.1016/j.ijadhadh.2019.102396
dc.identifier.issn0143-7496
dc.identifier.issn1879-0127
dc.identifier.scopus2-s2.0-85067229905en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.ijadhadh.2019.102396
dc.identifier.urihttps://hdl.handle.net/11616/98831
dc.identifier.volume95en_US
dc.identifier.wosWOS:000499734000002en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Sci Ltden_US
dc.relation.ispartofInternational Journal of Adhesion and Adhesivesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPolyurethaneen_US
dc.subjectBiomimeticen_US
dc.subjectTunable adhesionen_US
dc.subjectTweenen_US
dc.subjectSealing materialen_US
dc.titleBiomimetic approach to tunable adhesion of polyurethane adhesives through Fe3+ crosslinking and hydrophobic tween units with balance of adhesion/cohesion forcesen_US
dc.typeArticleen_US

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