Protective effects of molsidomine against doxorubicin-induced renal damage in rats

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dc.authoridTurkmen, Samdanci, Emine/0000-0002-0034-5186
dc.authoridPolat, Alaadin/0000-0002-6920-3856
dc.authoridParlakpınar, Hakan/0000-0001-9497-3468
dc.authoridParlakpinar, Hakan/0000-0001-9497-3468
dc.authoridKose, Evren/0000-0002-0246-2589
dc.authoridBeytur, Ali/0000-0002-7870-3318
dc.authoridyoldas, zeynep rumeysa/0000-0002-5608-9003
dc.authorwosidTurkmen, Samdanci, Emine/ABH-4716-2020
dc.authorwosidPolat, Alaadin/AAA-7171-2021
dc.authorwosidParlakpınar, Hakan/T-6517-2018
dc.authorwosidParlakpinar, Hakan/V-6637-2019
dc.authorwosidKose, Evren/ABG-9908-2020
dc.authorwosidBentli, Recep/AAB-4140-2021
dc.authorwosidBeytur, Ali/AAA-2823-2021
dc.contributor.authorOguz, Fatih
dc.contributor.authorBeytur, Ali
dc.contributor.authorSarihan, Ediz
dc.contributor.authorOguz, Hilal K.
dc.contributor.authorBentli, Recep
dc.contributor.authorSamdanci, Emine
dc.contributor.authorKose, Evren
dc.date.accessioned2024-08-04T20:42:55Z
dc.date.available2024-08-04T20:42:55Z
dc.date.issued2016
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPurpose: The purpose of this study was to investigate the therapeutic and protective effects of molsidomine (MLS) against doxorubicin (DOX)-induced renal damage in rats. Methods: Forty rats were randomly divided into five groups (control, MLS, DOX, DOX+MLS and MLS+DOX groups). Thiobarbituric acid reactive substance (TBARS), reduced glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), nitric oxide (NO) and glutathione peroxidase (GPx) levels were determined from kidney tissues and blood urea nitrogen (BUN), creatinine (Cr) and albumin (Alb) levels also determined. Results: DOX treatment caused a significant increase in TBARS levels and a significant decrease in the GSH and CAT levels compared with the control group. In comparison, MLS administration before DOX injection caused a significant decrease in TBARS levels and also increases in GSH and CAT levels, whereas treatment of MLS after DOX injection did not show any beneficial effect on these parameters. All groups showed a significant increase in NO levels compared to the control group. There were no significant differences among the all groups for BUN and Cr levels. Serum level of Alb decreased in the DOX-treated groups when compared with control and MLS groups. The histopathological findings were in accordance with the biochemical results. MLS treatment reversed the DOX-induced kidney damage in group 4. MLS treatment before DOX injection exerted a protective effect against DOX-induced kidney damage. Conclusions: MLS shows promise as a possible therapeutic intervention for the prevention of kidney injury associated with DOX treatment. Additional studies are warranted.en_US
dc.identifier.endpageE14en_US
dc.identifier.issn0147-958X
dc.identifier.issn1488-2353
dc.identifier.issue1en_US
dc.identifier.pmid26833172en_US
dc.identifier.scopus2-s2.0-85009968291en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpageE7en_US
dc.identifier.urihttps://hdl.handle.net/11616/97669
dc.identifier.volume39en_US
dc.identifier.wosWOS:000369142400002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherCanadian Soc Clinical Investigationen_US
dc.relation.ispartofClinical and Investigative Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectIschemia-Reperfusion Injuryen_US
dc.subjectAcid Phenethyl Esteren_US
dc.subjectNitric-Oxideen_US
dc.subjectInduced Nephrotoxicityen_US
dc.subjectToxicityen_US
dc.subjectCardiomyopathyen_US
dc.subjectAminoguanidineen_US
dc.subjectGlutathioneen_US
dc.subjectInhibitionen_US
dc.subjectApoptosisen_US
dc.titleProtective effects of molsidomine against doxorubicin-induced renal damage in ratsen_US
dc.typeArticleen_US

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