Nucleotide-Binding Oligomerization Domain-Containing Protein 2 Variants in Patients with Spontaneous Bacterial Peritonitis

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dc.authoridCagin, Yasir Furkan/0000-0002-2538-857X
dc.authoridHarputluoglu, Muhsin Murat Muhip/0000-0002-9415-147X
dc.authoridbilgic, yılmaz/0000-0002-2169-5548
dc.authoriderdogan, mehmet ali/0000-0002-1713-5695
dc.authoridOTLU, BARIS/0000-0002-6220-0521
dc.authoridDertli, Ramazan/0000-0002-6205-8983
dc.authorwosidCagin, Yasir Furkan/ABI-2709-2020
dc.authorwosidHarputluoglu, Muhsin Murat Muhip/ABI-3094-2020
dc.authorwosidbilgic, yılmaz/ABI-6432-2020
dc.authorwosidDertli, Ramazan/AAG-8764-2020
dc.authorwosiderdogan, mehmet ali/ABI-4675-2020
dc.authorwosidDertli, Ramazan/JAN-8786-2023
dc.authorwosidOTLU, BARIS/ABI-5532-2020
dc.contributor.authorHarputluoglu, Murat M. M.
dc.contributor.authorDertli, Ramazan
dc.contributor.authorOtlu, Baris
dc.contributor.authorDemirel, Ulvi
dc.contributor.authorYener, Ozkan
dc.contributor.authorBilgic, Yilmaz
dc.contributor.authorErdogan, Mehmet Ali
dc.date.accessioned2024-08-04T20:41:23Z
dc.date.available2024-08-04T20:41:23Z
dc.date.issued2016
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe occurrence of spontaneous bacterial peritonitis (SBP) is significantly increased in carriers of nucleotide-binding oligomerization domain-containing protein 2 (NOD2) variants, suggesting that local immune alterations might be implicated in bacterial translocation (BT). We aimed to assess the role of the NOD2 gene in conferring susceptibility to SBP. We also sought to determine whether levels of serum interleukin-6 (IL-6), lipopolysaccharide-binding protein, and soluble TNF-alpha receptor, along with the presence of bacterial DNA (bactDNA) in ascitic fluid, are appropriate markers for BT in patients with liver cirrhosis and SBP. A cohort of 171 patients was divided into two groups: patients with SBP (n = 82) and those without SBP (n = 89). The presence of the most common NOD2 variants (p.R702W, p.G908R, and c.3020insC) was determined in these patients. We detected the p.G908R variant in four patients (4.9 %) of the SBP group. No significant difference was observed between the SBP and non-SBP groups for NOD2 risk variants. The frequency of bactDNA in ascitic fluid was higher for patients with NOD2 variants than for patients without variants (p = 0.021). Serum IL-6 levels in the SBP group were higher than those in the non-SBP group. The frequent detection of bactDNA in ascites of patients with the p.G908R variant suggests there is a strong association between NOD2 risk variants and BT in SBP patients. In addition, increased serum IL-6 levels and bactDNA in ascitic fluid could be considered surrogate markers for BT in patients with cirrhosis.en_US
dc.identifier.doi10.1007/s10620-015-4024-y
dc.identifier.endpage1552en_US
dc.identifier.issn0163-2116
dc.identifier.issn1573-2568
dc.identifier.issue6en_US
dc.identifier.pmid26725065en_US
dc.identifier.scopus2-s2.0-84952659508en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1545en_US
dc.identifier.urihttps://doi.org/10.1007/s10620-015-4024-y
dc.identifier.urihttps://hdl.handle.net/11616/97093
dc.identifier.volume61en_US
dc.identifier.wosWOS:000376587600020en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofDigestive Diseases and Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNOD2en_US
dc.subjectBacterial translocationen_US
dc.subjectSpontaneous bacterial peritonitisen_US
dc.subjectCirrhosisen_US
dc.titleNucleotide-Binding Oligomerization Domain-Containing Protein 2 Variants in Patients with Spontaneous Bacterial Peritonitisen_US
dc.typeArticleen_US

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