Investigation of hepatocyte growth factor and proinflammatory cytokine levels in patients with febrile neutropenia

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dc.contributor.authorÖZDEN, MEHMET
dc.contributor.authorGÖDEKMERDAN, Ahmet
dc.contributor.authorİLHAN, Nafiye Fulya
dc.contributor.authorELKIRAN, EMİN TAMER
dc.contributor.authorAKBULUT, HATİCE HANDAN
dc.date.accessioned2020-06-23T06:13:48Z
dc.date.available2020-06-23T06:13:48Z
dc.date.issued2013
dc.departmentİnönü Üniversitesien_US
dc.description.abstractÖz (İngilizce): Aim: It has been thought that hepatocyte growth factor (HGF) levels increase during acute phases of infectious diseases. The aim of this study was to determine whether HGF, C-reactive protein (CRP), and proinflammatory cytokines have any diagnostic and prognostic value, and to assess HGF as a biomarker in patients with febrile neutropenia. Materials and methods: This study included 20 patients with febrile neutropenia as the study group and 20 healthy individuals as the control group. Serial measurements of serum HGF, CRP, and proinflammatory cytokine levels were performed by enzyme-linked immunosorbent assay (ELISA) at the baseline, after 48 h of treatment, and at posttreatment. Results: It was found that HGF levels at the baseline were significantly higher than those in the healthy controls (P = 0.001). It was also seen that HGF levels 48 h after treatment and at posttreatment were significantly lower than those at the baseline (P = 0.012). High-risk group patients had higher mean serum HGF levels compared with the low-risk group. It was detected that IL-6 and TNF-α levels at the baseline were significantly decreased after treatment (P = 0.02 and P = 0.005). Conclusion: Our findings suggested that serial measurement of serum HGF levels may be an important marker to identify risk levels of febrile neutropenia and to predict its prognosis.en_US
dc.identifier.citationMEHMET Ö. , Ahmet G. , Nafiye Fulya İ. , EMİN TAMER E. , HATİCE HANDAN A. (2013). Investigation of hepatocyte growth factor and proinflammatory cytokine levels in patients with febrile neutropenia , Turkish Journal of Medical Sciences İnönü Üniversitesi, Malatya.en_US
dc.identifier.endpage605en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue4en_US
dc.identifier.startpage599en_US
dc.identifier.trdizinid150355en_US
dc.identifier.urihttps://hdl.handle.net/11616/16000
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/150355
dc.identifier.volume43en_US
dc.identifier.wosWOS:000323609800019en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherTurkish Journal of Medical Sciencesen_US
dc.relation.ispartofTurkish Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCerrahien_US
dc.titleInvestigation of hepatocyte growth factor and proinflammatory cytokine levels in patients with febrile neutropeniaen_US
dc.typeArticleen_US

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