Benzotriazole functionalized N-heterocyclic carbene-silver(I) complexes: Synthesis, cytotoxicity, antimicrobial, DNA binding, and molecular docking studies

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dc.authoridcıkla, ışın kılıç/0000-0002-2407-0244
dc.authoridKarataş, Mert Olgun/0000-0001-8500-2088
dc.authoridAteş, Burhan/0000-0001-6080-229X
dc.authoridGürses, Canbolat/0000-0002-4085-0224
dc.authoridÖzdemir, Namık/0000-0003-3371-9874
dc.authoridBALCIOGLU, Sevgi/0000-0003-0724-4772
dc.authoridBALCIOGLU, Sevgi/0000-0003-0724-4772
dc.authorwosidcıkla, ışın kılıç/ABB-3913-2021
dc.authorwosidKarataş, Mert Olgun/ABG-7848-2020
dc.authorwosidAteş, Burhan/AAA-3730-2021
dc.authorwosidGürses, Canbolat/AAA-6825-2019
dc.authorwosidÖzdemir, Namık/J-6434-2015
dc.authorwosidBALCIOGLU, Sevgi/W-5874-2018
dc.authorwosidBALCIOGLU, Sevgi/O-3576-2015
dc.contributor.authorOnar, Gulnihan
dc.contributor.authorKaratas, Mert Olgun
dc.contributor.authorBalcioglu, Sevgi
dc.contributor.authorTok, Tugba Taskin
dc.contributor.authorGurses, Canbolat
dc.contributor.authorKilic-Cikla, Isin
dc.contributor.authorOzdemir, Namik
dc.date.accessioned2024-08-04T20:44:38Z
dc.date.available2024-08-04T20:44:38Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIn this study, six [Ag(NHC)(2)](+)[AgCl2](-) type silver complexes were synthesized by the reaction of corresponding carbene precursor and Ag2O. One [Ag(NHC)(2)]+NO3- type complex was synthesized by the anion exchange reaction of corresponding silver-NHC and NaNO3. The synthesized complexes were characterized by H-1 NMR, C-13 NMR and IR spectroscopic methods, and elemental analysis. X-ray crystal structure of 5a was also reported. Cytotoxicities of all compounds were evaluated against human breast (MCF-7) and colorectal (Caco-2) cancer cell lines and non-cancer mouse fibroblast (L-929) cell lines. All complexes performed stronger activity against both cancer cell lines than standard compound cisplatin while complex 3b performed nearly equal cytotoxicity to cisplatin against non-cancer L-929. Antimicrobial effects of all compounds were evaluated against Escherichia coli, Bacillus subtilis and Candida albicans and good activities were observed. The docking results indicated that complex 3b might be classified as druggable molecule in drug design. DNA binding study also demonstrates that 3b complex has an interaction ability to DNA. Combination of experimental and molecular docking results revealed that reported complexes are promising structures and deserve further research as anticancer drugs. (C) 2018 Elsevier Ltd. All rights reserved.en_US
dc.description.sponsorshipInonu University Research Fund (IUBAP Project) [2015-09 (GUD)]en_US
dc.description.sponsorshipThis study was financially supported by Inonu University Research Fund (IUBAP Project no: 2015-09 (GUD)).en_US
dc.identifier.doi10.1016/j.poly.2018.06.052
dc.identifier.endpage40en_US
dc.identifier.issn0277-5387
dc.identifier.issn1873-3719
dc.identifier.scopus2-s2.0-85049798207en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage31en_US
dc.identifier.urihttps://doi.org/10.1016/j.poly.2018.06.052
dc.identifier.urihttps://hdl.handle.net/11616/98380
dc.identifier.volume153en_US
dc.identifier.wosWOS:000444358300003en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofPolyhedronen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSilver(I)en_US
dc.subjectN-Heterocyclic carbeneen_US
dc.subjectBenzotriazoleen_US
dc.subjectCytotoxicityen_US
dc.subjectAntimicrobialen_US
dc.titleBenzotriazole functionalized N-heterocyclic carbene-silver(I) complexes: Synthesis, cytotoxicity, antimicrobial, DNA binding, and molecular docking studiesen_US
dc.typeArticleen_US

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