Clinical Evaluation of TNM-7 and TNM-8 Stages in Patients with Non-Small Cell Lung Cancer

Basit Öğe Kaydı
dc.contributor.authorGülmez, Ahmet
dc.contributor.authorAkdeniz, Nadiye
dc.date.accessioned2024-08-04T19:51:22Z
dc.date.available2024-08-04T19:51:22Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjectives: The AJCC/UICC TNM (tumor, node, metastasis) classification is a system used to describe the anatomical extent and stage grouping of solid malignant tumors. This system provides a worldwide standardization and is updated periodically. In this study, we aimed to compare the staging of patients with operated Non-Small Cell Lung Cancer (NSCLC) according to TNM-7 and TNM-8. Methods: In this study, we retrospectively analyzed data from 113 NSCLC patients resected without neoadjuvant therapy. Patients with another malignancy diagnosis were excluded from the study. Patients with multiple nodules were excluded because a clear TNM classification could not be made. We evaluated patients individually by restaging them using their post-operative pathology reports. Results: The stage distribution according to TNM7 was as follows: IA: 30 (26.5%), IB: 14 (12,3%), IIA: 36 (31,8%), IIB: 16 (14.2%), IIIA: 13 (11,5%), IIIB: 2 (1,7%). Staging the cases according to TNM8, there is no case was down-staged, 60 (53%) were upstaged; most pronounced between stages IIA (TNM7) to IIB (TNM8), and IIB (TNM7) to IIIA (TNM8). Most of the up stages did not change the adjuvant treatment decision. Approximately 6% of patients experienced a change from IB to IIA. Conclusion: In conclusion, a significant stage change was detected in patients whose stages were reevaluated using TNM7 and TNM8. Most of these upgrades do not change the treatment plan. This stage change may affect the adjuvant treatment decision in a small number of patients. With both classification systems, there was no statistical significance for disease-free survival (DFS) among subgroups, but the statistical significance for overall survival (OS).en_US
dc.identifier.doi10.14744/ejmi.2022.27919
dc.identifier.endpage386en_US
dc.identifier.issn2602-3164
dc.identifier.issue3en_US
dc.identifier.startpage383en_US
dc.identifier.trdizinid1133914en_US
dc.identifier.urihttps://doi.org/10.14744/ejmi.2022.27919
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1133914
dc.identifier.urihttps://hdl.handle.net/11616/88919
dc.identifier.volume6en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofEurasian Journal of Medical Investigationen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleClinical Evaluation of TNM-7 and TNM-8 Stages in Patients with Non-Small Cell Lung Canceren_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

TR-Dizin İndeksli Yayınlar Koleksiyonu