Comparison of Cajal-like cells in pelvis and proximal ureter of kidney with and without hydronephrosis

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dc.authoridOzkardes, Hakan/0000-0002-7277-449X
dc.authoridTurunc, Tahsin/0000-0002-7936-2172;
dc.authorwosidOzkardes, Hakan/AAH-1052-2020
dc.authorwosidTurunc, Tahsin/ABD-4332-2020
dc.authorwosidçelik, hüseyin/AAA-3033-2021
dc.contributor.authorBalikci, Omer
dc.contributor.authorTurunc, Tahsin
dc.contributor.authorBal, Nebil
dc.contributor.authorCelik, Huseyin
dc.contributor.authorOzkardes, Hakan
dc.date.accessioned2024-08-04T20:42:36Z
dc.date.available2024-08-04T20:42:36Z
dc.date.issued2015
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjectives: To evaluate effects of Cajal-like cells on human renal pelvis and proximal ureter on peristalsis. Materials and Methods: 63 patients submitted to nephrectomy due to atrophic non- functional kidney associated with hydroureteronephrosis were included as study group and 30 cases with nephrectomy due to other reasons were included as control group. Samples from renal pelvis and proximal ureters were obtained and sections of 5 mu form paraffin blocks of these samples were prepared; layers of lamina propria and muscularis mucosa were examined by immune-histochemistry using CD117 in order to determine count and distribution of Cajal-like cells. Results: During immune-histochemical examinations of sections, obtained from renal pelvis and proximal ureter of hydronephrotic kidneys by CD117, Cajal-like cells number determined in lamina propria and muscularis propria was statistically significantly lower compared to control group (p<0.001). Distribution of Cajal-like cells in renal pelvis and proximal tubulus was similar under examination by light microscope, and also both groups were not different from each other regarding staining intensity of Cajal-like cells by c-kit. Conclusion: Significantly reduced number of Cajal-like cells in study group compared to control group, shows that these cells may have a key role in regulation of peristalsis at level of renal pelvis and proximal ureter in urinary system.en_US
dc.description.sponsorshipBaskent University Institutional Review Board [KA10/04]; Baskent University Research Funden_US
dc.description.sponsorshipThis study was approved by Baskent University Institutional Review Board (Project no: KA10/04) and supported by Baskent University Research Fund.en_US
dc.identifier.doi10.1590/S1677-5538.IBJU.2014.0427
dc.identifier.endpage1184en_US
dc.identifier.issn1677-5538
dc.identifier.issn1677-6119
dc.identifier.issue6en_US
dc.identifier.pmid26742978en_US
dc.identifier.scopus2-s2.0-84983196993en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1178en_US
dc.identifier.urihttps://doi.org/10.1590/S1677-5538.IBJU.2014.0427
dc.identifier.urihttps://hdl.handle.net/11616/97479
dc.identifier.volume41en_US
dc.identifier.wosWOS:000368286600022en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBrazilian Soc Urolen_US
dc.relation.ispartofInternational Braz J Urolen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectInterstitial Cells of Cajalen_US
dc.subjectHydronephrosisen_US
dc.subjectUreteren_US
dc.titleComparison of Cajal-like cells in pelvis and proximal ureter of kidney with and without hydronephrosisen_US
dc.typeArticleen_US

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