Therapeutic plasma exchange in patients with neurological diseases: Multicenter retrospective analysis

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dc.authoridYILMAZ, Mehmet/0000-0002-5710-5263
dc.authoridErkurt, Mehmet Ali/0000-0002-3285-417X
dc.authoridKeklik, Muzaffer/0000-0002-6426-5249
dc.authoridokan, vahap/0000-0002-9869-8181
dc.authoridDogu, Mehmet Hilmi/0000-0001-7237-2637
dc.authoridCETIN, Mustafa/0000-0003-4512-1124
dc.authoridYılmaz, Mehmet/0000-0002-4368-8453
dc.authorwosidilhan, osman/ABC-8182-2021
dc.authorwosidYILMAZ, Mehmet/HKM-4739-2023
dc.authorwosidŞencan, Mehmet/AAA-9163-2022
dc.authorwosidErkurt, Mehmet Ali/ABI-7232-2020
dc.authorwosidKeklik, Muzaffer/B-3037-2016
dc.authorwosidokan, vahap/AAH-1424-2020
dc.authorwosidDogu, Mehmet Hilmi/W-2255-2017
dc.contributor.authorKaya, Emin
dc.contributor.authorKeklik, Muzaffer
dc.contributor.authorSencan, Mehmet
dc.contributor.authorYilmaz, Mehmet
dc.contributor.authorKeskin, Ali
dc.contributor.authorKiki, Ilhami
dc.contributor.authorErkurt, Mehmet Ali
dc.date.accessioned2024-08-04T20:37:38Z
dc.date.available2024-08-04T20:37:38Z
dc.date.issued2013
dc.departmentİnönü Üniversitesien_US
dc.description.abstractTherapeutic plasma exchange (TPE), is a procedure, changing pathologic substances in the plasma of patients with replacement fluid. TPE has an increasing list of indications in recent years such as neurological, connective tissue, hematological, nephrological, endocrinological and metabolic disorders. We report our multicenter data about therapeutic plasma exchange in patients with neurological diseases. Six University Hospitals' aphaeresis units medical records about neurologic diseases were reviewed retrospectively. Hundred and fifteen patients and 771 TPE sessions from six aphaeresis units' were included to this study. Of the 115 patients, 53 (46%) were men and 62 (54%) were women. The median age was 50 (range: 5-85) years. Of these patients 58.3% were Guillain-Barre syndrome (GBS), 17.4% were acute disseminated encephalomyelitis (ADEM), 10.4% were chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), 7% were multiple sclerosis, 6.1% were myasthenia gravis (MG) and 0.9% were Wilson disease (WD). The median number of TPE sessions per patient was 5 (range 1-72). Human albumin was used as a replacement fluid in 66% and fresh frozen plasma was used in 34% of cases. TPE was done through central venous catheters in 66%, and peripheral venous access in 34% of patients. Some complications were seen in patients (18.3%) during TPE sessions. These complications were, complications related to catheter placement procedure (8.7%), hypotension (3.5%), hypocalcaemia (3.5%) and allergic reactions (1.7%). The complication ratios were 2.7% in total 771 TPE procedures. TPE procedure was terminated in 6% of sessions depending on these complications. Overall responses to TPE were noted in 89.5% of patients. In conclusion: Therapeutic plasma exchange is an effective treatment option in several neurologic diseases. (C) 2013 Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.transci.2013.04.015
dc.identifier.endpage352en_US
dc.identifier.issn1473-0502
dc.identifier.issue3en_US
dc.identifier.pmid23619327en_US
dc.identifier.scopus2-s2.0-84878884255en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage349en_US
dc.identifier.urihttps://doi.org/10.1016/j.transci.2013.04.015
dc.identifier.urihttps://hdl.handle.net/11616/96093
dc.identifier.volume48en_US
dc.identifier.wosWOS:000321403400016en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofTransfusion and Apheresis Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTherapeutic plasma exchangeen_US
dc.subjectGuillain-Barre syndromeen_US
dc.subjectAcute disseminated encephalomyelitisen_US
dc.subjectChronic inflammatory demyelinating polyradiculoneuropathyen_US
dc.subjectMultiple sclerosisen_US
dc.subjectMyasthenia gravisen_US
dc.titleTherapeutic plasma exchange in patients with neurological diseases: Multicenter retrospective analysisen_US
dc.typeArticleen_US

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