Lycopene prevents experimental priapism against oxidative and nitrosative damage

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dc.authorscopusid27867577100
dc.authorscopusid11240091700
dc.authorscopusid8708323400
dc.authorscopusid7003321823
dc.authorscopusid6508157185
dc.authorscopusid14039543000
dc.contributor.authorCiftci O.
dc.contributor.authorOguz F.
dc.contributor.authorBeytur A.
dc.contributor.authorPolat F.
dc.contributor.authorAltintas R.
dc.contributor.authorOguzturk H.
dc.date.accessioned2024-08-04T20:00:49Z
dc.date.available2024-08-04T20:00:49Z
dc.date.issued2014
dc.departmentİnönü Üniversitesien_US
dc.description.abstractOBJECTIVE: Priapism is a persistent and often painful penile erection in the absence of sexual stimulation. It can cause progressive fibrosis, edema and drying of the erectile tissue and then it can lead to erectile dysfunction. Previous studies suggested that, neu-ronal nitric oxide levels increased during the pri-apism. High NO levels can result in the formation of reactive oxygen species (ROS) leading to oxidative stress in tissue and reproductive system. The aim of this study was to evaluate oxida-tive and nitrosative effects caused by priapism in cavernosal tissue and serum, and determinate beneficial effects of lycopene on ischemic pri-apism. MATERIALS AND METHODS: 32 rats were randomly divided into four groups and the first group being as the control. In the second group, experimental ischemic priapism was formed for an hour and then 1hour reperfusion was provided. In the third group, lycopene was intraperi-toneally given at the dose of 10 mg/kg. In the fourth group, lycopene were administered to rats with experimental priapism. RESULTS: Priapism caused a significant increase in TBARS (thiobarbituric acid reactive substances) and NO levels and a significant decrease in the levels of GSH, CAT, GPx and SOD in serum and cavernosal tissue of rats. However, lycopene significantly increased GSH, CAT, GPx and SOD levels but decreased formation of TBARS production and NO in rats with priapism. CONCLUSIONS: Our findings indicated that is-chemic priapism lead to significant oxidative and nitrosative damage in cavernosal tissue and serum samples of rats. However lycopene treatment eliminates these negative effects induced by priapism. For this reason, we suggested that lycopene may be used in the treatment of pri-apism.en_US
dc.identifier.endpage3325en_US
dc.identifier.issn1128-3602
dc.identifier.issue21en_US
dc.identifier.pmid25487946en_US
dc.identifier.scopus2-s2.0-84942278669en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage3320en_US
dc.identifier.urihttps://hdl.handle.net/11616/91026
dc.identifier.volume18en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherVerduci Editoreen_US
dc.relation.ispartofEuropean Review for Medical and Pharmacological Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCavernosal tissueen_US
dc.subjectLycopeneen_US
dc.subjectNitrosative stressen_US
dc.subjectOxidative stressen_US
dc.subjectPriapismen_US
dc.titleLycopene prevents experimental priapism against oxidative and nitrosative damageen_US
dc.typeArticleen_US

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