Protective Effect of Infliximab on Ischemia/Reperfusion-Induced Damage in Rat Kidney

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dc.authoridParlakpınar, Hakan/0000-0001-9497-3468
dc.authoridAcet, Ahmet/0000-0003-1131-1878
dc.authoridAteş, Burhan/0000-0001-6080-229X
dc.authoridParlakpinar, Hakan/0000-0001-9497-3468
dc.authoridVardı, Nigar/0000-0003-0576-1696
dc.authoridKati, B/0000-0002-4024-5147
dc.authoridKARAASLAN, MERVE GOKSIN/0000-0003-2645-808X
dc.authorwosidParlakpınar, Hakan/T-6517-2018
dc.authorwosidAcet, Ahmet/AAB-3273-2021
dc.authorwosidAteş, Burhan/AAA-3730-2021
dc.authorwosidParlakpinar, Hakan/V-6637-2019
dc.authorwosidKati, Bulent/AAQ-8835-2020
dc.authorwosidVardı, Nigar/C-9549-2018
dc.authorwosidKati, B/AGQ-3954-2022
dc.contributor.authorTasdemir, Cemal
dc.contributor.authorTasdemir, Seda
dc.contributor.authorVardi, Nigar
dc.contributor.authorAtes, Burhan
dc.contributor.authorParlakpinar, Hakan
dc.contributor.authorKati, Bulent
dc.contributor.authorKaraaslan, Merve Goksin
dc.date.accessioned2024-08-04T20:36:10Z
dc.date.available2024-08-04T20:36:10Z
dc.date.issued2012
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: To investigate the protective effect of infliximab on ischemia-reperfusion (I/R) injury of the rat kidney. Methods: Twenty-eight male Wistar albino rats were divided into four groups: sham-operated, I/R, I/R with infliximab administered before ischemia [I/R + infliximab (bi)], and I/R with infliximab administered before reperfusion [I/R + infliximab (br)]. After a right nephrectomy to produce damage, the left renal vessels were occluded for 60 min, followed by 24-h reperfusion in rats. Changes in the rat kidney were observed by measuring the tissue levels of malondialdehyde (MDA), myeloperoxidase (MPO), glutathione (GSH), and superoxide dismutase (SOD) and by evaluating hematoxylin-eosin (H&E)-stained and periodic acid-Schiff (PAS) sections. Results: The MDA and MPO levels in the I/R group were significantly higher than in the other groups (p < 0.05), and the SOD and GSH levels in the I/R + infliximab (bi) and I/R + infliximab (br) groups were significantly higher than in the I/R group (p < 0.05). However, histological examination revealed that the I/R + infliximab (bi) group and the I/R + infliximab (br) group had significantly fewer tubular changes and interstitial inflammatory cell infiltration than the I/R group. Conclusion: These results show that infliximab may protect against I/R injury in the rat I/R model.en_US
dc.identifier.doi10.3109/0886022X.2012.717490
dc.identifier.endpage1149en_US
dc.identifier.issn0886-022X
dc.identifier.issn1525-6049
dc.identifier.issue9en_US
dc.identifier.pmid22950848en_US
dc.identifier.scopus2-s2.0-84866401335en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1144en_US
dc.identifier.urihttps://doi.org/10.3109/0886022X.2012.717490
dc.identifier.urihttps://hdl.handle.net/11616/95802
dc.identifier.volume34en_US
dc.identifier.wosWOS:000308956200017en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofRenal Failureen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectischemia-reperfusionen_US
dc.subjectrenalen_US
dc.subjectinfliximaben_US
dc.titleProtective Effect of Infliximab on Ischemia/Reperfusion-Induced Damage in Rat Kidneyen_US
dc.typeArticleen_US

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