Effects of Intraperitoneally Administered Folic Acid on the Healing of Repaired Tibial Nerves in Rats

Basit Öğe Kaydı
dc.authoridSahin, Mehmet Sukru/0000-0001-7677-8423;
dc.authorwosidSahin, Mehmet Sukru/AAJ-9972-2021
dc.authorwosidHARMA, AHMET/AAB-3992-2021
dc.authorwosidZORLUDEMIR, SUZAN/AAA-4430-2022
dc.contributor.authorHarma, Ahmet
dc.contributor.authorSahin, Mehmet Sukru
dc.contributor.authorZorludemir, Suzan
dc.date.accessioned2024-08-04T20:40:14Z
dc.date.available2024-08-04T20:40:14Z
dc.date.issued2015
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground Complete nerve regeneration and clinical healing remain a challenge despite considerable advances in the treatment of peripheral nerve injuries. To improve nerve regeneration, several experimental molecular procedures have been attempted. This study aimed to investigate the effects of folic acid on peripheral nerve healing after transection and end-to-end suture repair of the tibial nerve in rats. Methods In this study, 20 adult male Wistar Albino rats weighing 225 to 250 g were used. The right tibial nerves of 20 rats were explored, transected, and sutured using the end-to-end technique. The rats were randomly allocated to either the intraperitoneally administered folic acid group (test group) or the control group. Preoperative and 6-week postoperative neurophysiological studies were performed by the same researcher. Myelin-sheathed axons were counted. Results The results demonstrated that the folic acid treated group exhibited improved electromyographic results compared with the control group. Histological evaluation revealed that the axons were well preserved and that the axon quantity and density were increased in the test group compared with the control group. Quantitative results also increased in the test group compared with the control group (p = 0.001). Conclusion In this study, 6-week intraperitoneal administration of 80 mu g/kg of folic acid significantly improved peripheral nerve healing. Histological analysis of the group that received folic acid revealed increased axon myelination with little granular tissue or fibrosis. We propose that folic acid supplementation may be an effective component of peripheral nerve injury treatment.en_US
dc.identifier.doi10.1055/s-0034-1395414
dc.identifier.endpage197en_US
dc.identifier.issn0743-684X
dc.identifier.issn1098-8947
dc.identifier.issue3en_US
dc.identifier.pmid25423028en_US
dc.identifier.scopus2-s2.0-84929991291en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage191en_US
dc.identifier.urihttps://doi.org/10.1055/s-0034-1395414
dc.identifier.urihttps://hdl.handle.net/11616/96795
dc.identifier.volume31en_US
dc.identifier.wosWOS:000350188800005en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherThieme Medical Publ Incen_US
dc.relation.ispartofJournal of Reconstructive Microsurgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectfolic aciden_US
dc.subjectperipheral nerveen_US
dc.subjectnerve repairen_US
dc.subjectregenerationen_US
dc.titleEffects of Intraperitoneally Administered Folic Acid on the Healing of Repaired Tibial Nerves in Ratsen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu