In vitro and in vivo acetylcholinesterase-inhibiting effect of new classes of organophosphorus compounds

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dc.authoridKUCUKBAY, HASAN/0000-0002-7180-9486
dc.authoridOzmen, Murat/0000-0003-4378-0839
dc.authorwosidOZMEN, MURAT/A-4874-2009
dc.authorwosidKUCUKBAY, HASAN/A-5050-2019
dc.contributor.authorOzmen, M
dc.contributor.authorSener, S
dc.contributor.authorMete, A
dc.contributor.authorKucukbay, H
dc.date.accessioned2024-08-04T20:12:01Z
dc.date.available2024-08-04T20:12:01Z
dc.date.issued1999
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAnticholinesterase properties of 14 new synthesized organophosphorus (OP) compounds and four of their starting substances were tested in vitro and in vivo using electric eel acetylcholinesterase (AChE) and Rana ridibunda (frog of lowland) tadpoles, respectively. Gusathion-M(R) was used as a reference anti-AChE agent. Acetylcholinesterase inhibition capacity of tested compounds was assayed for 30-min period in vitro studies using electric eel AChE, of which 14 OP compounds inhibited enzyme activity more than 50% within 30 min, excluding Gusathion-M. However, four of the compounds inhibited AChE less than 50% during the test period. On the other hand, 12 of the OPs did not bring about mortality, whereas six of the tested compounds were found to be lethal agents for R. ridibunda tadpoles, for which values of concentration causing 50% lethality ranged from 14.42 to 89.95 ppm. Also, the highest degree of enzyme inhibition occurred by diethyl chlorophosphate (ETCP), which inhibited AChE activity 62% at 2.89 ppm in 24-h toxicity tests and which was more effective than Gusathion-M. The lethal OP compounds represented good correlation between dose and enzyme-inhibition capability in in vivo tests, but only ETCP showed such a relation for anti-AChE effect in both in vitro and in vivo conditions.en_US
dc.identifier.doi10.1002/etc.5620180221
dc.identifier.endpage246en_US
dc.identifier.issn0730-7268
dc.identifier.issn1552-8618
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-0032910754en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage241en_US
dc.identifier.urihttps://doi.org/10.1002/etc.5620180221
dc.identifier.urihttps://hdl.handle.net/11616/93165
dc.identifier.volume18en_US
dc.identifier.wosWOS:000078254500021en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofEnvironmental Toxicology and Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectorganophosphonateen_US
dc.subjectacetylcholinesteraseen_US
dc.subjectelectric eelen_US
dc.subjectRana ridibundaen_US
dc.subjecttadpoleen_US
dc.titleIn vitro and in vivo acetylcholinesterase-inhibiting effect of new classes of organophosphorus compoundsen_US
dc.typeArticleen_US

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