Royal jelly regulates the caspase, Bax and COX-2, TNF-? protein pathways in the fluoride exposed lung damage in rats

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dc.authoridGök, Özlem/0000-0001-8521-6369
dc.authoridParlak, Gozde/0000-0002-8982-887X
dc.authoridGundogdu, Ramazan/0000-0001-5230-2121
dc.authoridCan, Muhammed Ismail/0000-0002-0118-2278
dc.authoridBaspinar, Serpil/0000-0001-9496-2451
dc.authoridAslan, Abdullah/0000-0002-6243-4221
dc.authorwosidcan, mi/KDN-4165-2024
dc.authorwosidCan, Muhammed İsmail/ABG-8646-2020
dc.authorwosidGök, Özlem/AFV-8223-2022
dc.authorwosidParlak, Gozde/ISA-6808-2023
dc.authorwosidGundogdu, Ramazan/U-3770-2018
dc.authorwosidBaspinar, Serpil/V-8526-2018
dc.authorwosidAslan, Abdullah/C-9523-2016
dc.contributor.authorAslan, Abdullah
dc.contributor.authorGok, Ozlem
dc.contributor.authorBeyaz, Seda
dc.contributor.authorCan, Muhammed Ismail
dc.contributor.authorParlak, Gozde
dc.contributor.authorGundogdu, Ramazan
dc.contributor.authorOzercan, Ibrahim Hanifi
dc.date.accessioned2024-08-04T20:51:39Z
dc.date.available2024-08-04T20:51:39Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe study was carried out on 42 male rats divided into six groups with 7 rats in each group: two control groups, two injury groups and two treatment groups. One of the control groups received a basal diet while the other one was fed a basal diet supplemented with royal jelly (RJ) (100 mg/kg). The two injury groups were given 50 mg/kg and 100 mg/kg fluoride, respectively. The two treatment groups exposed to 50 mg/kg and 100 mg/kg fluoride were both fed basal diets with RJ (100 mg/kg). Lungs were taken for histopathological examination. Spectrophotometric analysis was utilized to determine Malondialdehyde (MDA), catalase (CAT) and glutathione (GSH) activities, and Western blotting technique was used to evaluate the levels of specific proteins. On one hand, our experiments revealed that RJ caused decreased MDA levels, and downregulation of COX-2, Bcl-2, GSK3 and TNF?? protein expressions. On the other hand, rolay jelly caused augmented GSH and CAT activities, as well as upregulated Bax, BDNF, caspase-3, caspase-6, caspase-9 protein expressions in rats injuried by the fluoride exposure. The results suggest that the application of RJ was very likely to have a healing effect on the degenerative changes seen in the examined tissue.en_US
dc.description.sponsorshipFirat University Research Projects Unit (FUBAP) [FF.19.16]en_US
dc.description.sponsorshipThis study was supported by Firat University Research Projects Unit (FUBAP) [Project No: FF.19.16] .en_US
dc.identifier.doi10.1016/j.tice.2022.101754
dc.identifier.issn0040-8166
dc.identifier.pmid35158127en_US
dc.identifier.scopus2-s2.0-85124291439en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.tice.2022.101754
dc.identifier.urihttps://hdl.handle.net/11616/100469
dc.identifier.volume76en_US
dc.identifier.wosWOS:000798366700008en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherChurchill Livingstoneen_US
dc.relation.ispartofTissue & Cellen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectApoptosisen_US
dc.subjectLungen_US
dc.subjectNaFen_US
dc.subjectROSen_US
dc.subjectRoyal jellyen_US
dc.titleRoyal jelly regulates the caspase, Bax and COX-2, TNF-? protein pathways in the fluoride exposed lung damage in ratsen_US
dc.typeArticleen_US

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