Oxytocin and Vasopressin Blood Levels in People with Post-Traumatic Stress Disorder

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dc.contributor.authorZayman, Esra Porgali
dc.contributor.authorKarabulut, Aysun Bay
dc.contributor.authorOzdemir, Serdal
dc.contributor.authorKartalci, Sukru
dc.date.accessioned2024-08-04T20:11:44Z
dc.date.available2024-08-04T20:11:44Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: The neuroendocrine system and the hypothalamic-pituitary-adrenal axis are among the possible neurobiological factors that may be involved in the emergence and persistence of post-traumatic stress disorder. Here, we determined the levels of vaso-pressin and oxytocin in the peripheral blood of people with post-traumatic stress disorder, investigating their correlation with post-traumatic stress disorder symptoms. Methods: The study included patients with post-traumatic stress disorder according to the Diagnostic and Statistical Manual of Mental Disorders Version 4 and healthy controls. People who accepted to participate in the study, who did not have any additional diseases, who had the ability to understand the questionnaires, and who did not use medications during the 3 months preceding the study onset were enrolled. The levels of vasopressin and oxytocin were measured using the enzyme-linked immunosorbent assay. Results:Twenty-eight subjects with post-traumatic stress disorder and 19 healthy controls were included. The 2 groups were not significantly different in terms of oxytocin blood levels (P = .481). However, subjects with post-traumatic stress disorder had a significantly lower vasopressin level than controls (P < .001). We found no significant correlations of trauma duration and scale scores with oxytocin or vasopressin levels. Conclusion: The findings of this study show that blood vasopressin may play a role in post-traumatic stress disorder. Prospective studies based on a larger number of partici-pants are warranted to clarify how neuromodulators may affect the pathogenesis of post -traumatic stress disorder.en_US
dc.description.sponsorshipResearch Fund of the Inonu University [2011-15]en_US
dc.description.sponsorshipThis work was supported by Research Fund of the Inonu University. Project Number: 2011-15.en_US
dc.identifier.doi10.5152/alphapsychiatry.2023.21628
dc.identifier.issn2757-8038
dc.identifier.issue5en_US
dc.identifier.pmid38105782en_US
dc.identifier.trdizinid1250313en_US
dc.identifier.urihttps://doi.org/10.5152/alphapsychiatry.2023.21628
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1250313
dc.identifier.urihttps://hdl.handle.net/11616/92965
dc.identifier.volume24en_US
dc.identifier.wosWOS:001135569100002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAvesen_US
dc.relation.ispartofAlpha Psychiatryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPost-Traumatic Stress Disorderen_US
dc.subjectoxytocinen_US
dc.subjectvasopressinen_US
dc.titleOxytocin and Vasopressin Blood Levels in People with Post-Traumatic Stress Disorderen_US
dc.typeArticleen_US

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