Serum preptin düzeylerinin Tip 2 diabetes mellitus hastalarında mikrovasküler komplikasyonlar ve biyokimyasal belirteçler ile ilişkisi
Küçük Resim Yok
Tarih
2024
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
İnönü Üniversitesi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Bu çalışmanın amacı, Tip 2 Diabetes Mellitus (T2DM) hastalarında serum preptin düzeylerinin mikrovasküler komplikasyonlar ile ilişkisini araştırmaktır. Çalışmada, preptin düzeylerinin T2DM hastalarında diabetik nefropati, retinopati ve nöropati gibi mikrovasküler komplikasyonlarla olan olası bağlantısını ve bu biyomolekülün rutinde çalışılan biyokimyasal belirteçler ile olası bir ilişkisini araştırmaktaır. Materyal Metod: Bu çalışma, İnönü Üniversitesi Tıp Fakültesi İç Hastalıklar Anabilim Dalı Endokrinoloji Polikliniği'ne başvuran 222 hasta üzerinde gerçekleştirildi. Katılımcılardan 47'si sağlıklı kontrol grubundan, 175'i ise T2DM hastalarından oluşuyordu. T2DM hastaları, komplikasyonlarına göre dört gruba ayrıldı; Komplikasyon gelişmemiş grup, nefropati gelişmiş grup, retinopati gelişmiş grup ve nöropati gelişmiş grup. Katılımcılardan açlık sonrası kan örnekleri toplanarak biyokimyasal analizler yapıldı. Serum preptin düzeyleri ELISA yöntemi ile ölçüldü ve diğer biyokimyasal parametreler standart laboratuvar yöntemleri ile belirlendi. Bulgular: Komplikasyon gelişmemiş diabet grubunda serum preptin düzeyleri 687 [607; 850] ng/L (medyan [çeyrekler arası aralık]), retinopati 888 [780; 1261] ng/L ve nefropati 957 [688; 2346] ng/L gelişmiş diabet grubuna göre daha düşük bulundu. Kontrol grubunda serum preptin düzeyleri 1470 [700; 2906] ng/L tip 2 diabetlilerden 785 [671; 1092] ng/L yüksek bulundu. Kontrol grubunda serum preptin düzeyleri nöropati 752 [671; 814] ng/L gelişen hastalardan yüksek bulundu. Kontrol grubunda serum preptin seviyeleri komplikasyon gelişmemiş diabet grubundan yüksek bulundu. Kontrol grubunda serum preptin düzeyleri ile serum kreatinin düzeyleri arasında orta düzeyde bir korelasyon tespit edildi ? =0,372(p=0,012). Sonuç: Bu çalışmada, T2DM hastalarında serum preptin düzeylerinin mikrovasküler komplikasyonlar ve biyokimyasal belirteçlerle olan ilişkisi incelenmiştir. Bulgularımız, T2DM hastalarında preptin düzeylerinin diabetik nefropati, retinopati ve nöropati gibi mikrovasküler komplikasyonlarla bağlantılı olabileceğini göstermektedir. Bu durum, preptin düzeylerinin diabetik komplikasyonlar gelişiminde ve farklı komplikasyonlarda farklı serum konsantrasyon düzeyleri ile T2DM hastalarının izlenmesi için potansiyel bir biyobelirteç olarak kullanılabileceğini düşündürmektedir. Çalışmamızın sonuçları, preptin hormonunun T2DM hastalarında klinik değerlendirmede önemli bir role sahip olabileceğini ve ileride yapılacak çalışmalarda preptin düzeylerinin daha detaylı araştırılması gerektiğini vurgulamaktadır.
Objective: The aim of this study is to investigate the relationship between serum preptin levels and microvascular complications in patients with Type 2 Diabetes Mellitus (T2DM). The study focuses on exploring the potential association between preptin levels and microvascular complications such as diabetic nephropathy, retinopathy, and neuropathy in T2DM patients, as well as the possible relationship of this biomolecule with routinely studied biochemical markers. Materials and Methods: This study was conducted on 222 patients who presented to the Endocrinology Outpatient Clinic of the Department of Internal Medicine at Inonu University Faculty of Medicine. Of the participants, 47 were from the healthy control group, and 175 were T2DM patients. T2DM patients were divided into four groups based on their complications: the group without complications, the group with nephropathy, the group with retinopathy, and the group with neuropathy. Fasting blood samples were collected from the participants for biochemical analyses. Serum preptin levels were measured using the ELISA method, and other biochemical parameters were determined using standard laboratory methods. Results: Serum preptin levels in the diabetic group without complications were found to be lower at 687 [607; 850] ng/L (median [interquartile range]) compared to the diabetic groups with retinopathy at 888 [780; 1261] ng/L and nephropathy at 957 [688; 2346] ng/L. Serum preptin levels in the control group were found to be higher at 1470 [700; 2906] ng/L compared to 785 [671; 1092] ng/L in the Type 2 diabetic patients. Serum preptin levels in the control group were also found to be higher than in patients with neuropathy at 752 [671; 814] ng/L. Serum preptin levels in the control group were higher than those in the diabetic group without complications. A moderate correlation was detected between serum preptin levels and serum creatinine levels in the control group, with ? =0.372 (p=0.012). Conclusion: This study examined the relationship between serum preptin levels, microvascular complications, and biochemical markers in T2DM patients. Our findings suggest that preptin levels may be associated with microvascular complications such as diabetic nephropathy, retinopathy, and neuropathy in T2DM patients. This suggests that preptin levels could potentially be used as a biomarker for monitoring T2DM patients with diabetic complications, with different serum concentration levels in various complications. The results of our study highlight the potential clinical significance of the preptin hormone in T2DM patients and emphasize the need for further research on preptin levels in future studies.
Objective: The aim of this study is to investigate the relationship between serum preptin levels and microvascular complications in patients with Type 2 Diabetes Mellitus (T2DM). The study focuses on exploring the potential association between preptin levels and microvascular complications such as diabetic nephropathy, retinopathy, and neuropathy in T2DM patients, as well as the possible relationship of this biomolecule with routinely studied biochemical markers. Materials and Methods: This study was conducted on 222 patients who presented to the Endocrinology Outpatient Clinic of the Department of Internal Medicine at Inonu University Faculty of Medicine. Of the participants, 47 were from the healthy control group, and 175 were T2DM patients. T2DM patients were divided into four groups based on their complications: the group without complications, the group with nephropathy, the group with retinopathy, and the group with neuropathy. Fasting blood samples were collected from the participants for biochemical analyses. Serum preptin levels were measured using the ELISA method, and other biochemical parameters were determined using standard laboratory methods. Results: Serum preptin levels in the diabetic group without complications were found to be lower at 687 [607; 850] ng/L (median [interquartile range]) compared to the diabetic groups with retinopathy at 888 [780; 1261] ng/L and nephropathy at 957 [688; 2346] ng/L. Serum preptin levels in the control group were found to be higher at 1470 [700; 2906] ng/L compared to 785 [671; 1092] ng/L in the Type 2 diabetic patients. Serum preptin levels in the control group were also found to be higher than in patients with neuropathy at 752 [671; 814] ng/L. Serum preptin levels in the control group were higher than those in the diabetic group without complications. A moderate correlation was detected between serum preptin levels and serum creatinine levels in the control group, with ? =0.372 (p=0.012). Conclusion: This study examined the relationship between serum preptin levels, microvascular complications, and biochemical markers in T2DM patients. Our findings suggest that preptin levels may be associated with microvascular complications such as diabetic nephropathy, retinopathy, and neuropathy in T2DM patients. This suggests that preptin levels could potentially be used as a biomarker for monitoring T2DM patients with diabetic complications, with different serum concentration levels in various complications. The results of our study highlight the potential clinical significance of the preptin hormone in T2DM patients and emphasize the need for further research on preptin levels in future studies.
Açıklama
Tıp Fakültesi, Tıbbi Biyokimya Ana Bilim Dalı
Anahtar Kelimeler
Biyokimya, Biochemistry, Endokrinoloji ve Metabolizma Hastalıkları
