Genotoxicity testing of four textile dyes in two crosses of Drosophila using wing somatic mutation and recombination test

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dc.authoridYesilada, Elif/0000-0002-3743-5767
dc.authoridYologlu, Saim/0000-0002-9619-3462
dc.authoridYESILADA, ERDEM/0000-0002-1348-6033
dc.authorwosidYesilada, Elif/ABG-9600-2020
dc.authorwosidYologlu, Saim/ABI-8014-2020
dc.authorwosidYESILADA, ERDEM/E-4743-2011
dc.contributor.authorDogan, EE
dc.contributor.authorYesilada, E
dc.contributor.authorOzata, L
dc.contributor.authorYologlu, S
dc.date.accessioned2024-08-04T20:14:54Z
dc.date.available2024-08-04T20:14:54Z
dc.date.issued2005
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIn this study, four textile dyes, namely Astrazon Yellow, Red, Blue, and Black, were tested for their genotoxic effects in the wing cells of Drosophila melanogaster. Two crosses were used, the standard cross (ST) and the improved high-bioactivation cross (HB), the latter being characterized by increased sensitivity to the genotoxic effects of promutagens and procarcinogens. Three-day-old larvae were exposed to different concentrations of dyes. Commonly known mutagens were applied as positive controls. All concentrations of textile dyes, ethyl methanesulfonate ( EMS), and urethane caused a decrease in survival proportional to concentration used. EMS and urethane caused an increase in the number of all types of spots in both standard and high-bioactivation crosses. Compared to ST crosses, the number of induced spots in the HB cross treated with urethane was considerably high. Treatment of the standard and the high-bioactivation crosses with textile dyes gave positive results, apparent from increase in the frequency of the small single spots. Yellow and red dyes also increased the number of large single spots in both crosses, whereas the twin spots were positive only at the highest dose of yellow dye. All these results indicate that D. melanogaster wing spot test can be recommended as a suitable in vivo test for the determination of genotoxicity of textile dyes.en_US
dc.identifier.doi10.1081/DCT-200064473
dc.identifier.endpage301en_US
dc.identifier.issn0148-0545
dc.identifier.issn1525-6014
dc.identifier.issue3en_US
dc.identifier.pmid16051555en_US
dc.identifier.scopus2-s2.0-23244458285en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage289en_US
dc.identifier.urihttps://doi.org/10.1081/DCT-200064473
dc.identifier.urihttps://hdl.handle.net/11616/94040
dc.identifier.volume28en_US
dc.identifier.wosWOS:000231077800004en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofDrug and Chemical Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDrosophila melanogasteren_US
dc.subjectgenotoxicityen_US
dc.subjectSMARTen_US
dc.subjecttextile dyeen_US
dc.subjectwing spot testen_US
dc.titleGenotoxicity testing of four textile dyes in two crosses of Drosophila using wing somatic mutation and recombination testen_US
dc.typeArticleen_US

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