Effects of noopept on ocular, pancreatic and renal histopathology in streptozotocin induced prepubertal diabetic rats

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dc.authoridGürbüz, Perihan/0000-0002-6632-9197
dc.authoridDUZOVA, Halil/0000-0001-8123-2150
dc.authoridCETIN, Asli/0000-0003-3902-3210
dc.authorwosidGürbüz, Perihan/Y-4833-2018
dc.contributor.authorGurbuz, Perihan
dc.contributor.authorDuzova, Halil
dc.contributor.authorTaslidere, Asli Cetin
dc.contributor.authorGul, Cemile Ceren
dc.date.accessioned2024-08-04T20:53:33Z
dc.date.available2024-08-04T20:53:33Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractDiabetes mellitus (DM) is a chronic disease at all ages including childhood and puberty. Failure to treat DM can cause retinopathy, nephropathy and neuropathy. Endocrine and metabolic changes during the pubertal period complicate management of DM. Noopept is a cognitive enhancer that exhibits antidiabetic properties. We investigated the effect of noopept on the histopathology of the cornea, retina, kidney and pancreas in pubertal diabetic rats. We allocated 60 prepubertal male rats randomly into six groups of 10: untreated control (C), DM control (DC), noopept control (NC), DM + noopept (D + N), DM + insulin (D + I) and DM + insulin + noopept (D + I + N). DM was induced by streptozotocin in the DC, D + N, D + I and D + I + N groups. Noopept was administered to the NC, D + N and D + I + N groups; insulin was administered to the D + I and D + I + N groups for 14 days. On day 18 of the experiment, animals were sacrificed and eyes, kidneys and pancreata were excised for histological investigation. Renal tubule diameter and corneal and retinal thickness were increased significantly in DC groups compared to the control group. The D + I, D + N and D + I + N groups exhibited fewer DM induced pathological changes than the DC group. The D + I + N group exhibited no significant differences in renal tubule diameter and corneal and retinal thickness compared to the DC group. Our findings suggest that noopept is protective against DM end organ complications in streptozotocin induced diabetic pubertal rats.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [215S629]en_US
dc.description.sponsorshipThe research was supported by the Scientific and Technological Research Council of Turkey (TUBITAK), in the form of grant number [215S629].en_US
dc.identifier.doi10.1080/10520295.2023.2187460
dc.identifier.endpage325en_US
dc.identifier.issn1052-0295
dc.identifier.issn1473-7760
dc.identifier.issue5en_US
dc.identifier.pmid36946173en_US
dc.identifier.scopus2-s2.0-85150927170en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage314en_US
dc.identifier.urihttps://doi.org/10.1080/10520295.2023.2187460
dc.identifier.urihttps://hdl.handle.net/11616/101248
dc.identifier.volume98en_US
dc.identifier.wosWOS:000954751800001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofBiotechnic & Histochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCorneaen_US
dc.subjectdiabetes mellitusen_US
dc.subjecthistopathologyen_US
dc.subjectkidneyen_US
dc.subjectnoopepten_US
dc.subjectpancreasen_US
dc.subjectpubertal perioden_US
dc.subjectratsen_US
dc.subjectretinaen_US
dc.titleEffects of noopept on ocular, pancreatic and renal histopathology in streptozotocin induced prepubertal diabetic ratsen_US
dc.typeArticleen_US

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